C. Vasudevan and M. Levene, Epidemiology and aetiology of neonatal seizures, Semin Fetal Neonatal Med, vol.18, pp.185-91, 2013.

G. M. Ronen, S. Penney, and W. Andrews, The epidemiology of clinical neonatal seizures in Newfoundland: a population-based study, J Pediatr, vol.134, pp.71-76, 1999.

L. G. Van-rooij, M. C. Toet, and A. C. Van-huffelen, Effect of treatment of subclinical neonatal seizures detected with aEEG: randomized, controlled trial, Pediatrics, vol.125, pp.358-366, 2010.

, World Health Organization. Guidelines on neonatal seizures. Geneva: World Health Organization, 2011.

L. Hellström-westas, G. Boylan, and J. Ågren, Systematic review of neonatal seizure management strategies provides guidance on antiepileptic treatment, Acta Paediatr, vol.104, pp.123-132, 2015.

D. Booth and D. J. Evans, Anticonvulsants for neonates with seizures, Cochrane Database Syst Rev, p.4218, 2004.

M. J. Painter, M. S. Scher, and A. D. Stein, Phenobarbital compared with phenytoin for the treatment of neonatal seizures, N Engl J Med, vol.341, pp.485-494, 1999.

Y. Ben-ari, Excitatory actions of gaba during development: the nature of the nurture, Nat Rev Neurosci, vol.3, pp.728-767, 2002.
URL : https://hal.archives-ouvertes.fr/inserm-00484852

F. S. Silverstein and F. E. Jensen, Neonatal seizures, Ann Neurol, vol.62, pp.112-132, 2007.

V. I. Dzhala, K. V. Kuchibhotla, and J. C. Glykys, Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures, J Neurosci, vol.30, pp.11745-61, 2010.

P. Bittigau, M. Sifringer, and C. Ikonomidou, Antiepileptic drugs and apoptosis in the developing brain, Ann N Y Acad Sci, vol.993, pp.103-117, 2003.

A. L. Mruk, K. L. Garlitz, and N. R. Leung, Levetiracetam in neonatal seizures: a review, J Pediatr Pharmacol Ther, vol.20, pp.76-89, 2015.

R. Trollmann, J. Schneider, and S. Keller, HIF-1-regulated vasoactive systems are differentially involved in acute hypoxic stress responses of the developing brain of newborn mice and are not affected by levetiracetam, Brain Res, vol.1199, pp.27-36, 2008.

, , 2019.

J. Kim, A. Kondratyev, and K. Gale, Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy, J Pharmacol Exp Ther, vol.323, pp.165-73, 2007.

N. L. Maitre, C. Smolinsky, and J. C. Slaughter, Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures, J Perinatol, vol.33, pp.841-847, 2013.

F. S. Silverstein and D. M. Ferriero, Off-label use of antiepileptic drugs for the treatment of neonatal seizures, Pediatr Neurol, vol.39, pp.77-86, 2008.

C. Venkatesan, S. Young, and M. Schapiro, Levetiracetam for the treatment of seizures in neonatal hypoxic ischemic encephalopathy, J Child Neurol, vol.32, pp.210-214, 2017.

M. T. Shoemaker and J. S. Rotenberg, Levetiracetam for the treatment of neonatal seizures, J Child Neurol, vol.22, pp.95-103, 2007.

A. Fürwentsches, C. Bussmann, and G. Ramantani, Levetiracetam in the treatment of neonatal seizures: a pilot study, Seizure, vol.19, pp.185-194, 2010.

N. S. Abend, A. M. Gutierrez-colina, and H. M. Monk, Levetiracetam for treatment of neonatal seizures, J Child Neurol, vol.26, pp.465-70, 2011.

O. Khan, E. Chang, and C. Cipriani, Use of intravenous levetiracetam for management of acute seizures in neonates, Pediatr Neurol, vol.44, pp.265-274, 2011.

G. Ramantani, C. Ikonomidou, and B. Walter, Levetiracetam: safety and efficacy in neonatal seizures, Eur J Paediatr Neurol, vol.15, pp.1-7, 2011.

C. M. Sharpe, E. V. Capparelli, and A. Mower, A seven-day study of the pharmacokinetics of intravenous levetiracetam in neonates: marked changes in pharmacokinetics occur during the first week of life, Pediatr Res, vol.72, pp.43-52, 2012.

O. Khan, C. Cipriani, and C. Wright, Role of intravenous levetiracetam for acute seizure management in preterm neonates, Pediatr Neurol, vol.49, pp.340-343, 2013.

S. Tanriverdi, D. Terek, and O. A. Koroglu, Neonatal status epilepticus controlled with levetiracetam at Sturge Weber syndrome, Brain Dev, vol.35, pp.367-71, 2013.

S. L. Merhar, K. R. Schibler, and C. M. Sherwin, Pharmacokinetics of levetiracetam in neonates with seizures, J Pediatr, vol.159, pp.152-156, 2011.

E. Koklu, E. A. Ariguloglu, and S. Koklu, Levetiracetam-induced anaphylaxis in a neonate, Pediatr Neurol, vol.50, pp.192-196, 2014.

D. Mchugh, S. Lancaster, and L. Manganas, A systematic review of the efficacy of levetiracetam in neonatal seizures, Neuropediatrics, vol.49, pp.12-17, 2018.

A. W. Chan, J. M. Tetzlaff, and P. C. Gøtzsche, SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials, BMJ, vol.346, p.7586, 2013.

E. Saliba and T. Debillon, Hypothermia for hypoxic-ischemic encephalopathy in fullterm newborns, Arch Pediatr Organe Off Soc Francaise Pediatr, vol.17, pp.67-77, 2010.

M. Tod, V. Jullien, and G. Pons, Facilitation of drug evaluation in children by population methods and modelling, Clin Pharmacokinet, vol.47, pp.231-274, 2008.

C. M. Thompson, A. S. Puterman, and L. L. Linley, The value of a scoring system for hypoxic ischaemic encephalopathy in predicting neurodevelopmental outcome, Acta Paediatr, vol.86, pp.757-61, 1997.

J. Gosselin, S. Gahagan, and C. Amiel-tison, The amiel-tison neurological assessment at term: conceptual and methodological continuity in the course of follow-up, Ment Retard Dev Disabil Res Rev, vol.11, pp.34-51, 2005.

C. J. Wusthoff, D. J. Dlugos, and A. Gutierrez-colina, Electrographic seizures during therapeutic hypothermia for neonatal hypoxicischemic encephalopathy, J Child Neurol, vol.26, pp.724-732, 2011.

H. C. Glass, C. J. Wusthoff, and R. A. Shellhaas, Risk factors for EEG seizures in neonates treated with hypothermia: a multicenter cohort study, Neurology, vol.82, pp.1239-1283, 2014.

S. V. Jain, J. M. Zempel, and P. Srinivasakumar, Early EEG power predicts MRI injury in infants with hypoxic-ischemic encephalopathy, J Perinatol, vol.37, pp.541-547, 2017.

J. M. Rennie, G. Chorley, and G. B. Boylan, Non-expert use of the cerebral function monitor for neonatal seizure detection, Arch Dis Child Fetal Neonatal Ed, vol.89, pp.37-40, 2004.

A. Malone, C. A. Ryan, and A. Fitzgerald, Interobserver agreement in neonatal seizure identification, Epilepsia, vol.50, pp.2097-101, 2009.

D. M. Murray, G. B. Boylan, and I. Ali, Defining the gap between electrographic seizure burden, clinical expression and staff recognition of neonatal seizures, Arch Dis Child Fetal Neonatal Ed, vol.93, pp.187-91, 2008.

N. E. Lynch, N. J. Stevenson, and V. Livingstone, The temporal characteristics of seizures in neonatal hypoxic ischemic encephalopathy treated with hypothermia, Seizure, vol.33, pp.60-65, 2015.

, , 2019.