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3 (white) and Mel270 (black) were grown alone or cocultured with LX-2 cells. B. LX-2 cells were grown alone or co-cultured with OMM2.3 (white) or Mel270 (black) cells. C. OMM2.3 (white) and Mel270 (black) were grown alone or co-cultured with LX-2 cells. D. LX-2 cells were grown alone or co-cultured with OMM2.3 (white) or Mel270 (black) cells. Transcripts listed in A to D were selected on the basis of the significance for their differential expression in monoculture versus co-culture conditions ,
, Quantitative analysis of the expression of integrin transcripts in co-cultures of UMCs and HSCs
, The quantification is presented as percentage of relative expression in grayscale, where the largest value appears in black (100%), and the smallest value in white (0%). B. LX-2 cells were grown alone or in coculture with UMCs (LX-2/Mel270, LX-2/OMM2.3). C. Mel270 and OMM2.3 cells were grown alone or cocultured with HSCs (Mel270/LX-2, OMM2.3/LX-2). Total RNA was harvested after 48 hours and the expression of integrins ITGA1, A. Heatmap of the relative expression of alpha and beta integrin subunits in LX-2 cells and UMCs grown alone or in co-culture
, Total proteins from Mel270, OMM2.3, and LX-2 cells grown alone or in co-culture conditions (Mel270/LX-2, OMM2.3/LX-2, LX-2/Mel270, LX-2/OMM2.3) and treated with TCZ were harvested after 48 hours. The expression of phosphor-STAT3 and total STAT3 was quantified by Western blotting (?-Actin, control loading). B-D. Cell proliferation was measured 48 hours post-TCZ treatment using the MTT colorimetric assays. E-H. Total RNA from Mel270, OMM2.3 and LX-2 cells grown alone or in co-culture conditions