Ethanolamine Produced from Oleoylethanolamide Degradation Contributes to Acetylcholine/Dopamine Balance Modulating Eating Behavior

Abstract : Oleoylethanolamide is a well-recognized anorectic compound which also has noteworthy effects on food-reward, influencing the acetylcholine (ACh)/dopamine (DA) balance in the cholinergic system. After its administration, oleoylethanolamide is quickly degraded into oleic acid and ethanolamine. The effect of oleic acid on the gut-brain axis has been extensively investigated, whereas ethanolamine has received scarce attention. However, there is scattered evidence from old and recent research that has underlined the influence of ethanolamine on the cholinergic system. In the present article, we propose a model by which the released ethanolamine contributes to the overall balance between DA and ACh after oleoylethanolamide administration.
Document type :
Journal articles
Complete list of metadatas

Cited literature [25 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-02050393
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, September 10, 2019 - 10:22:22 AM
Last modification on : Thursday, September 12, 2019 - 3:40:38 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2019-10-04

Please log in to resquest access to the document

Identifiers

Citation

Ilario Mennella, Gaëlle Boudry, David Val-Laillet. Ethanolamine Produced from Oleoylethanolamide Degradation Contributes to Acetylcholine/Dopamine Balance Modulating Eating Behavior. Journal of Nutrition, American Society for Nutrition, 2019, 149 (3), pp.362-365. ⟨10.1093/jn/nxy281⟩. ⟨hal-02050393⟩

Share

Metrics

Record views

33