Néo-ovogenèse dans l’ovaire adulte: Mythe ou réalité?

Sophie Sun (1) , Céline Pimentel (1) , Marina Yefimova (2) , Sylvie Jaillard (3, 1) , Célia Ravel (3)

1 CHU Pontchaillou [Rennes]
2 Sechenov Institute of Evolutionary Physiology and Biochemistry
3 Irset - Institut de recherche en santé, environnement et travail

For more than a decade, the existence of ovarian stem cells that can contribute to neo-oogenesis in the adult ovary is reported by some teams, challenging the dogma according to which mammalian females are born with a fixed and non-renewed germinal cell pool. The presence of germinal stem cells with mitotic activity suggests the possibility of potential postnatal oogenesis. These cells have both germ-line and stem cell markers in culture. They have been isolated using different strategies and their ability to differentiate into oocytes has been demonstrated since after reintroduction in an ovarian somatic environment, these cells generate follicles capable of producing healthy offspring in rodents. However, many scientists remain skeptical and question the reliability of the methods used. Despite that there is no consensus on the origin of these ovarian stem cells, private companies are now proposing to use their stem cell potential to treat human infertility.

Keywords: DDX4; Stem cell; Ovary

Keywords: cellules souches; ovaires

Domains: Life Sciences [q-bio]; Human health and pathology; Gynecology and obstetrics; Life Sciences [q-bio]; Development Biology; Gametogenesis

Sophie Sun, Céline Pimentel, Marina Yefimova, Sylvie Jaillard, Célia Ravel. Néo-ovogenèse dans l’ovaire adulte: Mythe ou réalité?. Gynécologie Obstétrique Fertilité & Sénologie, 2019, 47 (5), pp.478-483. ⟨10.1016/j.gofs.2019.02.011⟩. ⟨hal-02061950⟩