Circulating levels of CXCL11 and CXCL12 are biomarkers of cirrhosis in patients with chronic hepatitis C infection

Abstract : The chemokines CXCL10 (interferon ϒ-inducible protein 10 [IP-10]), CXCL11 (Human interferon inducible T cell alpha chemokine [I-TAC]), and CXCL12 (stromal cell derived factor 1 [SDF-1]) contribute to cell recruitment, migration, activation, and homing in liver diseases and their serum levels have been shown to be associated with the degree of liver inflammation or fibrosis in various etiologies. However, the data may be contradictory or insufficient, particularly for CXCL12, in the field of chronic HCV infection. Here, we aimed to provide evidence for these chemokines as biomarkers for chronic HCV infection.
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Journal articles
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-02061951
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Submitted on : Friday, March 8, 2019 - 2:22:37 PM
Last modification on : Monday, April 8, 2019 - 4:30:59 PM

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Arnaud Chalin, Benjamin Lefèvre, Christelle Devisme, Nathalie Barget, Laurence Amiot, et al.. Circulating levels of CXCL11 and CXCL12 are biomarkers of cirrhosis in patients with chronic hepatitis C infection. Cytokine, 2019, 117, pp.72-78. 〈10.1016/j.cyto.2019.02.006〉. 〈hal-02061951〉

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