Effet des acides gras polyinsaturés à longue chaîne n-3 sur le remodelage membranaire induit par les toxiques chimiques : retentissement sur la mort cellulaire

Abstract : Homeostasis of plasma membrane is crucial for the regulation of many cell processes such as inflammation, cell proliferation, migration or death. This especially dynamic cell structure can undergo alteration when exposed to a wide range of chemical toxicants, thus triggering a membrane stress signal that can change the activation of intracellular signalling pathways, involved in such phenomena. Yet, long chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) are described as capable of changing physicochemical properties of membranes. Thus, LC n-3 PUFA can possibly counteract or potentiate the effects of chemical toxicants with a membrane action. In this paper, we will mainly be interested in hepatotoxicants, notably benzo(a)pyrene, an environmental pollutant of the polycyclic aromatic hydrocarbon family, also found in cigarette smoke, and ethanol, the hepatoxicant prototype, whose human exposure is linked to lifestyle.
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Odile Sergent, Normand Podechard, Dominique Lagadic-Gossmann. Effet des acides gras polyinsaturés à longue chaîne n-3 sur le remodelage membranaire induit par les toxiques chimiques : retentissement sur la mort cellulaire. Cahiers de Nutrition et de Diététique, Elsevier Masson, 2019, 54 (2), pp.116-127. ⟨10.1016/j.cnd.2018.11.001⟩. ⟨hal-02062013⟩

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