Abstract : An efficient method for the reductive amination of carbonyl derivatives with ω-amino fatty acids catalysed by an iron complex Fe(CO) (IMes) [IMes=1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene] by means of hydrosilylation was developed. A variety of pyrrolidines, piperidines and azepanes were selectively synthesised in moderate-to-excellent yields (36 examples, 47-97 % isolated yield) with a good functional group tolerance.
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02087806
Contributor : Laurent Jonchère
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Submitted on : Thursday, July 18, 2019 - 11:33:59 AM
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