Iron-Catalysed Reductive Amination of Carbonyl Derivatives with ω-Amino Fatty Acids to Access Cyclic Amines

Abstract : An efficient method for the reductive amination of carbonyl derivatives with ω-amino fatty acids catalysed by an iron complex Fe(CO) (IMes) [IMes=1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene] by means of hydrosilylation was developed. A variety of pyrrolidines, piperidines and azepanes were selectively synthesised in moderate-to-excellent yields (36 examples, 47-97 % isolated yield) with a good functional group tolerance.
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Duo Wei, Chakkrit Netkaew, Victor Carre, Christophe Darcel. Iron-Catalysed Reductive Amination of Carbonyl Derivatives with ω-Amino Fatty Acids to Access Cyclic Amines. ChemSusChem, ChemPubSoc Europe/Wiley, 2019, 12 (3), pp.3008-3012. ⟨10.1002/cssc.201900519⟩. ⟨hal-02087806⟩

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