Iron-Catalysed Reductive Amination of Carbonyl Derivatives with ω-Amino Fatty Acids to Access Cyclic Amines

Duo Wei; Chakkrit Netkaew; Victor Carre; Christophe Darcel

Iron-Catalysed Reductive Amination of Carbonyl Derivatives with ω-Amino Fatty Acids to Access Cyclic Amines

Duo Wei ¹ Chakkrit Netkaew ¹ Victor Carre ¹ Christophe Darcel ¹

1 ISCR - Institut des Sciences Chimiques de Rennes

Abstract : An efficient method for the reductive amination of carbonyl derivatives with ω-amino fatty acids catalysed by an iron complex Fe(CO) (IMes) [IMes=1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene] by means of hydrosilylation was developed. A variety of pyrrolidines, piperidines and azepanes were selectively synthesised in moderate-to-excellent yields (36 examples, 47-97 % isolated yield) with a good functional group tolerance.

Keywords : iron catalysis reductive amination ω-amino fatty acids cyclic amines hydrosilylation

Document type :

Journal articles

Domain :

Chemical Sciences / Organic chemistry

Chemical Sciences / Catalysis

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https://hal-univ-rennes1.archives-ouvertes.fr/hal-02087806
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Submitted on : Thursday, July 18, 2019 - 11:33:59 AM
Last modification on : Thursday, July 18, 2019 - 11:38:09 AM

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