NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21, Nature, vol.441, pp.595-600, 2006. ,
Differential effects of duration and age on the consequences of neuroinflammation in the hippocampus, Neurobiol Aging, vol.34, pp.2293-2301, 2013. ,
Dyrk1 inhibition improves Alzheimer's disease-like pathology, Aging Cell: Doi, 2017. ,
A high-performance liquid chromatography assay for Dyrk1a, a Down syndrome-associated kinase, Anal Biochem, vol.449, pp.172-178, 2014. ,
Reactive gliosis and the multicellular response to CNS damage and disease, Neuron, vol.81, pp.229-248, 2014. ,
A novel role of the STAT3 pathway in brain inflammation-induced human neural progenitor cell differentiation, Curr Mol Med, vol.13, pp.1474-1484, 2013. ,
Amyloid-beta causes memory impairment by disturbing the JAK2/ STAT3 axis in hippocampal neurons, Mol Psychiatry, vol.14, pp.206-222, 2009. ,
Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing, J med Chem, vol.54, pp.4172-4186, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00870007
Molecular mapping of twenty-four features of Down syndrome on chromosome 21, Eur J Hum Genet, vol.1, pp.114-124, 1993. ,
Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders, Trends Pharmacol Sci, vol.29, pp.402-412, 2008. ,
Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, pick disease, and related transgenic models, Neurobiol Dis, vol.20, pp.392-400, 2005. ,
Viral gene transfer of APPsalpha rescues synaptic failure in an Alzheimer's disease mouse model, Acta Neuropathol, 2015. ,
Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation, FEBS J, vol.276, pp.6324-6337, 2009. ,
TREM2 variants in Alzheimer's disease, N Engl J med, vol.368, pp.117-127, 2013. ,
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, Science, vol.297, pp.353-356, 2002. ,
Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology, Acta Neuropathol, 2017. ,
Aging in Down syndrome and the development of Alzheimer's disease neuropathology, Curr Alzheimer Res, vol.13, pp.18-29, 2016. ,
The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus, J Recept Signal Transduct Res, vol.19, pp.75-120, 1999. ,
Neuroinflammation in Alzheimer's disease, Lancet Neurol, vol.14, pp.388-405, 2015. ,
Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice, J Neurosci, vol.28, p.8354, 2008. ,
Systemic inflammation and disease progression in Alzheimer disease, Neurology, vol.73, pp.768-774, 2009. ,
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase, Hum Mol Genet, vol.13, pp.159-170, 2004. ,
Truncation and activation of dual specificity tyrosine phosphorylation-regulated kinase 1A by Calpain I: a MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE, J Biol Chem, vol.290, pp.15219-15237, 2015. ,
Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII, J Biol Chem, vol.271, pp.3488-3495, 1996. ,
Calpain is a mediator of preservation-reperfusion injury in rat liver transplantation, Proc Natl Acad Sci U S A, vol.94, pp.9354-9359, 1997. ,
DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model, EMBO rep, vol.16, pp.1548-1562, 2015. ,
Neurotoxicity induces cleavage of p35 to p25 by calpain, Nature, vol.405, pp.360-364, 2000. ,
Neurotoxic reactive astrocytes are induced by activated microglia, Nature, vol.541, pp.481-487, 2017. ,
Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome, FASEB J, vol.22, pp.7-104539, 2008. ,
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice, Am J Pathol, vol.181, pp.616-625, 2012. ,
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature, Expert Opin Ther Pat, vol.27, pp.1183-1199, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-02046302
PEST sequences and regulation by proteolysis, Trends Biochem Sci, vol.21, pp.267-271, 1996. ,
Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs, FASEB J, vol.25, pp.3896-3905, 2011. ,
Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease, J Neurochem, vol.104, pp.1333-1344, 2008. ,
DYRK1A-mediated hyperphosphorylation of tau. A functional link between Down syndrome and Alzheimer disease, J Biol Chem, vol.282, pp.34850-34857, 2007. ,
Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer's disease, J Neurochem, vol.115, pp.574-584, 2010. ,
Innate immune system and inflammation in Alzheimer's disease: from pathogenesis to treatment, Neuroimmunomodulation, vol.21, pp.79-87, 2014. ,
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease, Neuron, vol.49, pp.489-502, 2006. ,
Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?, ACS Chem Neurosci, vol.3, pp.857-872, 2012. ,
Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators, Neuroscientist, vol.20, pp.160-172, 2014. ,
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B, J med Chem, vol.55, pp.9312-9330, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00870472
Intrathecal inflammation precedes development of Alzheimer's disease, J Neurol Neurosurg Psychiatry, vol.74, pp.1200-1205, 2003. ,
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease, J Clin Invest, vol.118, pp.2796-2807, 2008. ,
Mechanisms of specificity in protein phosphorylation, Nat Rev Mol Cell Biol, vol.8, pp.530-541, 2007. ,
Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer's disease, J Neurosci, vol.30, pp.6873-6881, 2010. ,
The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase, Biochem J, vol.355, pp.609-615, 2001. ,
Prefrontal cortex and hippocampus subserve different components of working memory in rats, Learn Mem, vol.15, pp.97-105, 2008. ,
TREM2 is a receptor for beta-amyloid that mediates microglial function, Zhang Met al, vol.97, pp.1023-1031, 2018. ,
Serine/threonine kinase mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the met adaptor ran-binding protein M, J Biol Chem, vol.278, pp.49573-49581, 2003. ,