Physical inactivity as the culprit of metabolic inflexibility: evidence from bed-rest studies, J. Appl. Physiol. Bethesda Md, vol.111, pp.1201-1210, 1985. ,
Effect of physical inactivity on the oxidation of saturated and monounsaturated dietary Fatty acids: results of a randomized trial, PLoS Clin. Trials, vol.1, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00157670
A rapid method of total lipid extraction and purification, Can. J. Biochem. Physiol, vol.37, pp.911-917, 1959. ,
A procedure for fractionation of sphingolipid classes by solid-phase extraction on aminopropyl cartridges, J. Lipid Res, vol.41, pp.1524-1531, 2000. ,
Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms, Physiol. Rev, vol.97, pp.1351-1402, 2017. ,
Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes, Arch. Biochem. Biophys, vol.419, pp.101-109, 2003. ,
The Regulation of NF-?B Subunits by Phosphorylation, 2016. ,
Intramyocellular Ceramides: Subcellular Concentrations and Fractional De Novo Synthesis in Postabsorptive Humans, Diabetes, vol.66, pp.2082-2091, 2017. ,
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus, J. Clin. Invest, vol.76, pp.149-155, 1985. ,
The economic burden of physical inactivity: a global analysis of major non-communicable diseases, Lancet Lond. Engl, vol.388, pp.1311-1324, 2016. ,
AICAR inhibits ceramide biosynthesis in skeletal muscle, Diabetol. Metab. Syndr, vol.4, p.45, 2012. ,
Physical inactivity, insulin resistance, and the oxidative-inflammatory loop, Free Radic. Res, vol.48, pp.93-108, 2014. ,
Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE, J. Biol. Chem, vol.291, pp.3019-3029, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01340226
Global physical activity levels: surveillance progress, pitfalls, and prospects, Lancet Physical Activity Series Working Group, vol.380, issue.12, pp.60646-60647, 2012. ,
Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers, Arterioscler. Thromb. Vasc. Biol, vol.27, pp.2650-2656, 2007. ,
Ceramide in the eukaryotic stress response, Trends Cell Biol, vol.10, pp.73-80, 2000. ,
Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice, J. Biol. Chem, vol.280, pp.10284-10289, 2005. ,
Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance, Cell Metab, vol.5, pp.167-179, 2007. ,
Contraction-stimulated glucose transport in muscle is controlled by AMPK and mechanical stress but not sarcoplasmatic reticulum Ca2+ release, Mol. Metab, vol.3, pp.742-753, 2014. ,
Immobilization rapidly induces muscle insulin resistance together with the activation of MAPKs (JNK and p38) and impairment of AS160 phosphorylation, 2016. ,
Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men, J. Appl. Physiol. Bethesda Md, vol.113, pp.7-15, 1985. ,
A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity, J. Appl. Physiol. Bethesda Md, vol.108, pp.1034-1040, 1985. ,
Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary exercise, J. Physiol, vol.562, pp.829-838, 2005. ,
Intramyocellular ceramides and skeletal muscle mitochondrial respiration are partially regulated by Toll-like receptor 4 during hindlimb unloading, Am. J. Physiol. Regul. Integr. Comp. Physiol, vol.311, pp.879-887, 2016. ,
Cessation of daily wheel running differentially alters fat oxidation capacity in liver, muscle, and adipose tissue, J. Appl. Physiol. Bethesda Md, vol.106, pp.161-168, 1985. ,
Effects of sphingolipid synthesis inhibition on cholesterol gallstone formation in C57BL/6J mice, J. Gastroenterol. Hepatol, vol.25, pp.1105-1110, 2010. ,
Effect of physical inactivity on major noncommunicable diseases worldwide: an analysis of burden of disease and life expectancy, Lancet Physical Activity Series Working Group, vol.380, pp.61031-61040, 2012. ,
Reducing Sphingolipid Synthesis Orchestrates Global Changes to Extend Yeast Lifespan, Aging Cell, vol.12, pp.833-841, 2013. ,
The SUMO conjugating enzyme Ubc9 is a regulator of GLUT4 turnover and targeting to the insulin-responsive storage compartment in 3T3-L1 adipocytes, Diabetes, vol.56, pp.1977-1985, 2007. ,
Prolonged insulin stimulation down-regulates GLUT4 through oxidative stress-mediated retromer inhibition by a protein kinase CK2-dependent mechanism in 3T3-L1 adipocytes, J. Biol. Chem, vol.289, pp.133-142, 2014. ,
Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man, Diabetologia, vol.28, pp.412-419, 1985. ,
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5, Diabetes, vol.57, pp.860-867, 2008. ,
Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.25, pp.3646-3660, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00623157
Muscle-Specific IRS-1 Ser?Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle, Diabetes, vol.57, pp.2644-2651, 2008. ,
Development of whole-body and skeletal muscle insulin resistance after one day of hindlimb suspension, Metabolism, vol.53, pp.1215-1222, 2004. ,
Metabolic responses to reduced daily steps in healthy nonexercising men, JAMA, vol.299, pp.1261-1263, 2008. ,
The diseasome of physical inactivity--and the role of myokines in muscle--fat cross talk, J. Physiol, vol.587, pp.5559-5568, 2009. ,
Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle, JCI Insight, vol.3, 2018. ,
From physical inactivity to immobilization: Dissecting the role of oxidative stress in skeletal muscle insulin resistance and atrophy. Free Radic, Biol. Med, vol.98, pp.197-207, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01255823
,
Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, J. Physiol, vol.586, pp.4241-4249, 2008. ,
Changes in skeletal muscle mitochondria in response to the development of type 2 diabetes or prevention by daily wheel running in hyperphagic OLETF rats, Am. J. Physiol. Endocrinol. Metab, vol.298, pp.1179-1187, 2010. ,
Acute inactivity impairs glycemic control but not blood flow to glucose ingestion, Med. Sci. Sports Exerc, vol.47, pp.1087-1094, 2015. ,
Potential clinical translation of juvenile rodent inactivity models to study the onset of childhood obesity, Am. J. Physiol. Regul. Integr. Comp. Physiol, vol.303, pp.247-258, 2012. ,
Myriocin prevents muscle ceramide accumulation but not muscle fiber atrophy during short-term mechanical unloading, J. Appl. Physiol. Bethesda Md, vol.120, pp.178-187, 1985. ,
URL : https://hal.archives-ouvertes.fr/hal-01231413
Mechanisms for insulin resistance: common threads and missing links, Cell, vol.148, pp.852-871, 2012. ,
Effect of insulin on the rates of synthesis and degradation of GLUT1 and GLUT4 glucose transporters in 3T3-L1 adipocytes, Biochem. J, vol.290, pp.913-919, 1993. ,
Targeting Ceramide Synthesis to Reverse Insulin Resistance, Diabetes, vol.59, pp.2351-2353, 2010. ,
Surrogate markers of insulin resistance: A review, World J. Diabetes, vol.1, pp.36-47, 2010. ,
Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteins, PloS One, vol.7, 2012. ,
Suppression of systemic, intramuscular, and subcutaneous adipose tissue lipolysis by insulin in humans, J. Clin. Endocrinol. Metab, vol.85, pp.3740-3745, 2000. ,
Oleate-enriched diet improves insulin sensitivity and restores muscle protein synthesis in old rats, Clin. Nutr. Edinb. Scotl, vol.30, pp.799-806, 2011. ,
Curcumin limits weight gain, adipose tissue growth, and glucose intolerance following the cessation of exercise and caloric restriction in rats, J. Appl. Physiol. Bethesda Md, vol.123, pp.1625-1634, 1985. ,
Association between hyperinsulinemia and increased risk of cancer death in nonobese and obese people: A population-based observational study, Int. J. Cancer, vol.141, pp.102-111, 2017. ,
Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption, Diabetes, vol.59, pp.2453-2464, 2010. ,
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes, Genome Biol, vol.3, p.34, 2002. ,
Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome, Am. J. Physiol. Endocrinol. Metab, vol.297, pp.211-224, 2009. ,
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