Iron-catalyzed carbonylative alkyl-acylation of heteroarenes

Abstract : Herein we present an efficient carbonylative protocol for the introduction of an alkyl-acyl group into heteroarenes from cyclobutanone oximes. In the presence of Fe(OTf) 2 catalyst, proceeds via intermolecular alkyl-acylation of different heteroarenes. A broad range of alkyl heteroaryl ketones are synthesized with excellent functional group tolerance with good chemoselectivity. © 2019 Elsevier Inc.
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Z. Yin, Z. Zhang, Jean-François Soulé, P.H. Dixneuf, X.-F. Wu. Iron-catalyzed carbonylative alkyl-acylation of heteroarenes. Journal of Catalysis, Elsevier, 2019, 372, pp.272-276. ⟨10.1016/j.jcat.2019.03.001⟩. ⟨hal-02089999⟩



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