J. A. Aguiar, A. Tamminga, B. Lobb, R. D. Huff, J. P. Nguyen et al., The impact of cigarette smoke exposure, COPD, or asthma status on ABC transporter gene expression in human airway epithelial cells, p.153, 2019.

J. Alam and J. L. Cook, Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway, Curr Pharm Des, vol.9, pp.2499-2511, 2003.

N. Bach, A. K. Bolling, B. C. Brinchmann, A. I. Totlandsdal, T. Skuland et al., Cytokine responses induced by diesel exhaust particles are suppressed by PAR-2 silencing and antioxidant treatment, and driven by polar and non-polar soluble constituents, Toxicol Lett, vol.238, pp.72-82, 2015.
DOI : 10.1016/j.toxlet.2015.07.002

A. Baulig, M. Garlatti, V. Bonvallot, A. Marchand, R. Barouki et al., Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells, Am J Physiol Lung Cell Mol Physiol, vol.285, pp.671-679, 2003.

A. E. Boitano, J. Wang, R. Romeo, L. C. Bouchez, A. E. Parker et al., Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells, Science, vol.329, pp.1345-1348, 2010.
DOI : 10.1126/science.1191536
URL : http://europepmc.org/articles/pmc3033342?pdf=render

C. Bosquillon, Drug transporters in the lung--do they play a role in the biopharmaceutics of inhaled drugs?, J Pharm Sci, vol.99, pp.2240-2255, 2010.

D. Cao, P. A. Bromberg, and J. M. Samet, Diesel particle-induced transcriptional expression of p21 involves activation of EGFR, Src, and Stat3, Am J Respir Cell Mol Biol, vol.42, pp.88-95, 2010.

E. Courcot, J. Leclerc, J. J. Lafitte, E. Mensier, S. Jaillard et al., Xenobiotic metabolism and disposition in human, 2012.

C. Ehrhardt, P. Backman, W. Couet, C. Edwards, B. Forbes et al., Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs, J Pharm Sci, vol.106, pp.2234-2244, 2017.

S. Endter, U. Becker, N. Daum, H. Huwer, C. M. Lehr et al., P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers, Cell Tissue Res, vol.328, pp.77-84, 2007.

A. J. Ghio, C. B. Smith, and M. C. Madden, Diesel exhaust particles and airway inflammation, Curr Opin Pulm Med, vol.18, pp.144-150, 2012.

K. M. Giacomini, S. M. Huang, D. J. Tweedie, L. Z. Benet, K. L. Brouwer et al., Membrane transporters in drug development, Nat Rev Drug Discov, vol.9, pp.215-236, 2010.

H. Glavinas, P. Krajcsi, J. Cserepes, and B. Sarkadi, The role of ABC transporters in drug resistance, metabolism and toxicity, Curr Drug Deliv, vol.1, pp.27-42, 2004.

M. J. Gold, P. R. Hiebert, H. Y. Park, D. Stefanowicz, A. Le et al., Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization, Mucosal Immunol, vol.9, pp.809-820, 2016.

S. Hanada, A. Maeshima, Y. Matsuno, T. Ohta, M. Ohki et al., Expression profile of early lung adenocarcinoma: identification of MRP3 as a molecular marker for early progression, J Pathol, vol.216, pp.75-82, 2008.

T. J. Hughes, J. Lewtas, and L. D. Claxton, Development of a standard reference material for diesel mutagenicity in the Salmonella plate incorporation assay, Mutat Res, vol.391, pp.243-258, 1997.

M. Jaguin, O. Fardel, and V. Lecureur, Exposure to diesel exhaust particle extracts (DEPe) impairs some polarization markers and functions of human macrophages through activation of AhR and Nrf2, PLoS One, vol.10, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01122723

E. Jouan, M. Le-vee, C. Denizot, Y. Parmentier, and O. Fardel, Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells, vol.9, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01477210

S. G. Klein, S. Cambier, J. Hennen, S. Legay, T. Serchi et al., Endothelial responses of the alveolar barrier in vitro in a dose-controlled exposure to diesel exhaust particulate matter, Part Fibre Toxicol, vol.14, p.7, 2017.

J. Konig, F. Muller, and M. F. Fromm, Transporters and drug-drug interactions: important determinants of drug disposition and effects, Pharmacol Rev, vol.65, pp.944-966, 2013.

L. Vee, M. Jouan, E. Lecureur, V. Fardel, and O. , Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells, Toxicol Appl Pharmacol, vol.290, pp.74-85, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01237095

L. Vee, M. Jouan, E. Stieger, B. Lecureur, V. Fardel et al., Regulation of human hepatic drug transporter activity and expression by diesel exhaust particle extract, PLoS One, vol.10, p.121232, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01138535

E. M. Leslie, R. G. Deeley, and S. P. Cole, Multidrug resistance proteins: role of Pglycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense, Toxicol Appl Pharmacol, vol.204, pp.216-237, 2005.

N. Li, J. Alam, M. I. Venkatesan, A. Eiguren-fernandez, D. Schmitz et al., Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals, J Immunol, vol.173, pp.3467-3481, 2004.

N. Li, M. Hao, R. F. Phalen, W. C. Hinds, and A. E. Nel, Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects, Clin Immunol, vol.109, pp.250-265, 2003.

C. M. Mahaffey, N. C. Mahaffey, W. Holland, H. Zhang, D. R. Gandara et al., Aberrant regulation of the MRP3 gene in non-small cell lung carcinoma, J Thorac Oncol, vol.7, pp.34-39, 2012.

C. M. Mahaffey, H. Zhang, A. Rinna, W. Holland, P. C. Mack et al., Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma, Free Radic Biol Med, vol.46, pp.1650-1657, 2009.

C. Manzano, E. Hoh, and S. L. Simonich, Quantification of complex polycyclic aromatic hydrocarbon mixtures in standard reference materials using comprehensive twodimensional gas chromatography with time-of-flight mass spectrometry, J Chromatogr A, vol.1307, pp.172-179, 2013.

G. G. Mason, Dioxin-receptor ligands in urban air and vehicle exhaust, Environ Health Perspect, vol.102, pp.111-116, 1994.

. A-c-c-e-p-t-e-d-m-a-n-u-s-c-r-i-p-t-20,

A. Mayati, A. Moreau, M. Le-vee, A. Bruyere, E. Jouan et al., Functional polarization of human hepatoma HepaRG cells in response to forskolin, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01973693

A. Moreau, M. Le-vee, E. Jouan, Y. Parmentier, and O. Fardel, Drug transporter expression in human macrophages, Fundam Clin Pharmacol, vol.25, pp.743-752, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00873191

S. D. Mundandhara, S. Becker, and M. C. Madden, Effects of diesel exhaust particles on human alveolar macrophage ability to secrete inflammatory mediators in response to lipopolysaccharide, Toxicol In Vitro, vol.20, pp.614-624, 2006.

A. Nakayama, H. Matsuo, T. Takada, K. Ichida, T. Nakamura et al., ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans, Nucleosides Nucleotides Nucleic Acids, vol.30, pp.1091-1097, 2011.

D. W. Nebert, T. P. Dalton, A. B. Okey, and F. J. Gonzalez, Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer, J Biol Chem, vol.279, pp.23847-23850, 2004.

D. W. Nebert, A. L. Roe, M. Z. Dieter, W. A. Solis, Y. Yang et al., Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis, Biochem Pharmacol, vol.59, pp.65-85, 2000.

T. Nguyen, C. S. Yang, and C. B. Pickett, The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress, Free Radic Biol Med, vol.37, pp.433-441, 2004.

G. Oberdorster and J. N. Finkelstein, In vitro dosing of cells with poorly soluble particles, Toxicol Sci, vol.94, 2006.

A. B. Okey, D. S. Riddick, and P. A. Harper, The Ah receptor: mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds, Toxicol Lett, vol.70, pp.1-22, 1994.

L. Palkova, J. Vondracek, L. Trilecova, M. Ciganek, K. Pencikova et al., The aryl hydrocarbon receptor-mediated and genotoxic effects of fractionated extract of standard reference diesel exhaust particle material in pulmonary, liver and prostate cells, Toxicol In Vitro, vol.29, pp.438-448, 2015.

L. Payen, A. Courtois, J. P. Campion, A. Guillouzo, and O. Fardel, Characterization and inhibition by a wide range of xenobiotics of organic anion excretion by primary human hepatocytes, Biochem Pharmacol, vol.60, pp.1967-1975, 2000.

A. Pronk, J. Coble, and P. A. Stewart, Occupational exposure to diesel engine exhaust: a literature review, J Expo Sci Environ Epidemiol, vol.19, pp.443-457, 2009.

T. Prueksaritanont, X. Chu, C. Gibson, D. Cui, K. L. Yee et al., Drug-drug interaction studies: regulatory guidance and an industry perspective, AAPS J, vol.15, pp.629-645, 2013.

M. Rius, J. Hummel-eisenbeiss, and D. Keppler, ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4), J Pharmacol Exp Ther, vol.324, pp.86-94, 2008.

A. Rosati, L. Candussio, E. Crivellato, F. B. Klugmann, T. Giraldi et al., Bodipy-FL-verapamil: a fluorescent probe for the study of multidrug resistance proteins, Cell Oncol, vol.26, pp.3-11, 2004.

A. Sakamoto, T. Matsumaru, N. Yamamura, S. Suzuki, Y. Uchida et al., Drug Transporter Protein Quantification of Immortalized Human Lung Cell Lines Derived from Tracheobronchial Epithelial Cells (Calu-3 and BEAS2-B), Bronchiolar-Alveolar Cells (NCI-H292 and NCI-H441), and Alveolar Type II-like Cells (A549) by Liquid Chromatography-Tandem Mass Spectrometry, J Pharm Sci, vol.104, pp.3029-3038, 2015.

K. Sayyed, M. L. Vee, Z. Abdel-razzak, E. Jouan, B. Stieger et al., Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate, Toxicology, vol.363, issue.364, pp.58-71, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01367143

A. H. Schinkel and J. W. Jonker, Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview, Adv Drug Deliv Rev, vol.55, pp.3-29, 2003.

J. C. Schneider, G. L. Card, J. C. Pfau, and A. Holian, Air pollution particulate SRM 1648 causes oxidative stress in RAW 264.7 macrophages leading to production of prostaglandin E2, a potential Th2 mediator, Inhal Toxicol, vol.17, pp.871-877, 2005.

T. Souza, D. Jennen, J. Van-delft, M. Van-herwijnen, S. Kyrtoupolos et al., New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis, Arch Toxicol, vol.90, pp.1449-1458, 2016.

L. Sparfel, J. Van-grevenynghe, M. Le-vee, C. Aninat, and O. Fardel, Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha, Carcinogenesis, vol.27, pp.656-663, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00699629

S. Steiner, C. Bisig, A. Petri-fink, and B. Rothen-rutishauser, Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms, Arch Toxicol, vol.90, pp.1541-1553, 2016.

C. E. Stewart, E. E. Torr, N. H. Mohd-jamili, C. Bosquillon, and I. Sayers, Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research, J Allergy, p.943982, 2012.

S. Tanigawa, M. Fujii, and D. X. Hou, Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin, Free Radic Biol Med, vol.42, pp.1690-1703, 2007.

R. K. Thimmulappa, K. H. Mai, S. Srisuma, T. W. Kensler, M. Yamamoto et al., Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray, Cancer Res, vol.62, pp.5196-5203, 2002.

A. R. Torky, E. Stehfest, K. Viehweger, C. Taege, and H. Foth, Immuno-histochemical detection of MRPs in human lung cells in culture, Toxicology, vol.207, pp.437-450, 2005.

. A-c-c-e-p-t-e-d-m-a-n-u-s-c-r-i-p-t-22,

M. Van-der-deen, E. G. De-vries, W. Timens, R. J. Scheper, H. Timmer-bosscha et al., Cigarette smoke extract affects functional activity of MRP1 in bronchial epithelial cells, J Biochem Mol Toxicol, vol.6, pp.243-251, 2005.

J. Van-grevenynghe, L. Sparfel, M. Le-vee, D. Gilot, B. Drenou et al., Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages, Biochem Biophys Res Commun, vol.317, pp.708-716, 2004.

H. E. Wichmann, Diesel exhaust particles, Inhal Toxicol, vol.19, issue.1, pp.241-244, 2007.

L. C. Young, B. G. Campling, T. Voskoglou-nomikos, S. P. Cole, R. G. Deeley et al., Expression of multidrug resistance protein-related genes in lung cancer: correlation with drug response, Clin Cancer Res, vol.5, pp.673-680, 1999.

S. F. Zhou, L. L. Wang, Y. M. Di, C. C. Xue, W. Duan et al., Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development, Curr Med Chem, vol.15, pp.1981-2039, 2008.

. A-c-c-e-p-t-e-d-m-a-n-u-s-c-r-i-p-t,