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Perspectives dans la maladie de Gorham–Stout

Abstract : The Gorham–Stout disease belongs to lymphatic abnormalities and corresponds to a lymphatic endothelial cell proliferation under the stimulation of growth factors. This proliferation leads to a bone invasion and progressively to a typical vanishing bone aspect. Fracture risk and its consequences, chylothorax with sometimes fatal issue are the main complications of this disease. Physiopathological mechanisms remain poorly understood. Treatments of this rare bone disease, susceptible to affect every age from infant to adults, rely on bisphosphonates, radiotherapy, surgery, interferon alpha 2b and anti-angiogenic drugs such as sunitinib.
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Submitted on : Thursday, May 23, 2019 - 9:56:36 AM
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C. Estublier, P. Chavassieux, E. Vignot, P. Guggenbuhl, C.B. Confavreux. Perspectives dans la maladie de Gorham–Stout. Revue du Rhumatisme monographies, Elsevier, 2019, 86 (2), pp.126-131. ⟨10.1016/j.monrhu.2018.12.003⟩. ⟨hal-02094605⟩



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