Perspectives dans la maladie de Gorham–Stout

Abstract : The Gorham–Stout disease belongs to lymphatic abnormalities and corresponds to a lymphatic endothelial cell proliferation under the stimulation of growth factors. This proliferation leads to a bone invasion and progressively to a typical vanishing bone aspect. Fracture risk and its consequences, chylothorax with sometimes fatal issue are the main complications of this disease. Physiopathological mechanisms remain poorly understood. Treatments of this rare bone disease, susceptible to affect every age from infant to adults, rely on bisphosphonates, radiotherapy, surgery, interferon alpha 2b and anti-angiogenic drugs such as sunitinib.
Complete list of metadatas

Cited literature [29 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-02094605
Contributor : Laurent Jonchère <>
Submitted on : Thursday, May 23, 2019 - 9:56:36 AM
Last modification on : Tuesday, May 28, 2019 - 1:48:46 PM

File

Estublier et al_2018_Perspecti...
Files produced by the author(s)

Identifiers

Citation

C. Estublier, P. Chavassieux, E. Vignot, P. Guggenbuhl, C.B. Confavreux. Perspectives dans la maladie de Gorham–Stout. Revue du Rhumatisme monographies, Elsevier, 2019, 86 (2), pp.126-131. ⟨10.1016/j.monrhu.2018.12.003⟩. ⟨hal-02094605⟩

Share

Metrics

Record views

26

Files downloads

35