Targeting the PD-1/PD-L1 Pathway in Renal Cell Carcinoma

Abstract : Renal cell carcinoma encompass distinct diseases with different pathologic features and distinct molecular pathways. Immune checkpoint inhibitors targeting the programmed death receptor ligand 1 (PD-L1)/programmed death receptor 1 (PD-1) pathway alone or in combination have greatly changed clinical management of metastatic renal cell carcinoma, now competing with antiangiogenic drugs in monotherapy for first-line treatment. However, long-term response rates are low, and biomarkers are needed to predict treatment response. Quantification of PD-L1 expression by immunohistochemistry was developed as a promising biomarker in clinical trials, but with many limitations (different antibodies, tumour heterogeneity, specimens, and different thresholds of positivity). Other biomarkers, including tumour mutational burden and molecular signatures, are also developed and discussed in this review.
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Journal articles
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-02119178
Contributor : Xavier Chard-Hutchinson <>
Submitted on : Friday, May 3, 2019 - 4:05:50 PM
Last modification on : Thursday, July 11, 2019 - 1:02:28 AM

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Solène-Florence Kammerer-Jacquet, Antoine Deleuze, Judikaël Saout, Romain Mathieu, Brigitte Laguerre, et al.. Targeting the PD-1/PD-L1 Pathway in Renal Cell Carcinoma. International Journal of Molecular Sciences, MDPI, 2019, 20 (7), pp.E1692. ⟨10.3390/ijms20071692⟩. ⟨hal-02119178⟩

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