Skip to Main content Skip to Navigation
Journal articles

Insights into the Link between the Organization of DNA Replication and the Mutational Landscape

Abstract : The generation of a complete and accurate copy of the genetic material during each cell cycle is integral to cell growth and proliferation. However, genetic diversity is essential for adaptation and evolution, and the process of DNA replication is a fundamental source of mutations. Genome alterations do not accumulate randomly, with variations in the types and frequencies of mutations that arise in different genomic regions. Intriguingly, recent studies revealed a striking link between the mutational landscape of a genome and the spatial and temporal organization of DNA replication, referred to as the replication program. In our review, we discuss how this program may contribute to shaping the profile and spectrum of genetic alterations, with implications for genome dynamics and organismal evolution in natural and pathological contexts.
Document type :
Journal articles
Complete list of metadata

Cited literature [95 references]  Display  Hide  Download
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Tuesday, July 7, 2020 - 3:30:25 PM
Last modification on : Thursday, March 31, 2022 - 4:12:10 AM
Long-term archiving on: : Friday, November 27, 2020 - 2:04:02 PM


Publication funded by an institution


Distributed under a Creative Commons Attribution 4.0 International License



Julia Gaboriaud, Pei-Yun Jenny Wu. Insights into the Link between the Organization of DNA Replication and the Mutational Landscape. Genes, MDPI, 2019, 10 (4), pp.E252. ⟨10.3390/genes10040252⟩. ⟨hal-02119225⟩



Record views


Files downloads