Doxorubicin-induced congestive heart failure in elderly patients with metastatic breast cancer, with long-term follow-up: the MD Anderson experience, Cancer Chemother. Pharmacol, vol.43, pp.471-478, 1999. ,
Anthracycline chemotherapy and cardiotoxicity. Cardiovasc, Drugs Ther, vol.31, pp.63-75, 2017. ,
Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells, Biochem. Pharmacol, vol.46, pp.375-382, 1993. ,
Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II, Science, vol.226, pp.466-468, 1984. ,
Repair of double-strand breaks by end joining. Cold Spring Harbor Perspect, Biol, vol.5, p.12757, 2013. ,
DNA-dependent conformational changes in the Ku heterodimer, Biochemistry, vol.47, pp.4359-4368, 2008. ,
Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini, Mol. Cell. Biol, vol.18, pp.5908-5920, 1998. ,
At loose ends: resecting a double-strand break, Cell, vol.137, pp.807-810, 2009. ,
Repair pathway choices and consequences at the double-strand break, Trends Cell Biol, vol.26, pp.52-64, 2016. ,
Purified human BRCA2 stimulates RAD51-mediated recombination, Nature, vol.467, p.678, 2010. ,
Collaboration and competition between DNA doublestrand break repair pathways, FEBS Lett, vol.584, pp.3703-3708, 2010. ,
Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A, Nature, vol.391, p.407, 1998. ,
Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52--ssDNA complexes, Nucleic Acids Res, vol.38, pp.2917-2930, 2010. ,
Human Rad52-mediated homology search and annealing occurs by continuous interactions between overlapping nucleoprotein complexes, Proc. Natl. Acad. Sci. USA 105, pp.20274-20279, 2008. ,
A requirement for polymerized actin in DNA double-strand break repair, Nucleus, vol.3, pp.384-395, 2012. ,
DNA damage induces nuclear actin filament assembly by formin-2 and Spire-1/2 that promotes efficient DNA repair, Elife, vol.4, p.7735, 2015. ,
Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes, Nat. Struct. Mol. Biol, vol.24, pp.353-361, 2017. ,
Nuclear F-actin and myosins drive relocalization of heterochromatic breaks, Nature, vol.559, pp.54-60, 2018. ,
Nuclear ARP2/3 drives DNA break clustering for homologydirected repair, Nature, vol.559, pp.61-66, 2018. ,
Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin, J. Biol. Chem, vol.269, pp.14869-14871, 1994. ,
, Schematic model of the interaction of RPA-2 with nuclear actin and its alteration by actin depolymerizing or polymerizing compounds
The chondramides: cytostatic agents from myxobacteria acting on the actin cytoskeleton, J. Natl. Cancer Inst, vol.90, pp.1559-1563, 1998. ,
Inhibition of actin polymerization by latrunculin A, FEBS Lett, vol.213, pp.316-318, 1987. ,
Latrunculin a has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice, Anticancer Res, vol.29, pp.2091-2097, 2009. ,
The actin targeting compound Chondramide inhibits breast cancer metastasis via reduction of cellular contractility, PLoS ONE, vol.9, p.112542, 2014. ,
Jasplakinolide: interaction with radiation and hyperthermia in human prostate carcinoma and Lewis lung carcinoma, Cancer Chemother. Pharmacol, vol.42, pp.491-496, 1998. ,
I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks, DNA Repair Protoc, vol.920, pp.379-391, 2012. ,
Discovery and biological activity of new chondramides from Chondromyces sp, Chembiochem, vol.14, pp.1573-1580, 2013. ,
A flow cytometry-based method to simplify the analysis and quantification of protein association to chromatin in mammalian cells, Nat. Protoc, vol.10, pp.1297-1307, 2015. ,
Vacuolar-ATPase inhibition blocks iron metabolism to mediate therapeutic effects in breast cancer, Cancer Res, vol.75, pp.2863-2874, 2015. ,
Targeting the actin cytoskeleton: selective antitumor action via trapping PKC?, Cell Death Dis, vol.5, p.1398, 2014. ,
Dynamizing nuclear actin filaments, Curr. Opin. Cell. Biol, vol.56, pp.1-6, 2018. ,
Enhanced cellular radiosensitivity induced by cofilin-1 overexpression is associated with reduced DNA repair capacity, Int. J. Radiat. Biol, vol.89, pp.433-444, 2013. ,
DNA damage in cancer therapeutics: a boon or a curse?, Cancer Res, vol.75, pp.2133-2138, 2015. ,
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining, Biochem. J, vol.417, pp.639-650, 2009. ,
Transcriptional effects of actin-binding compounds: the cytoplasm sets the tone, Cell. Mol. Life Sci, 2018. ,
Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein, Science, vol.314, pp.464-467, 2006. ,
A role for nuclear actin in HDAC 1 and 2 regulation, Sci. Rep, vol.6, p.28460, 2016. ,
Actinlatrunculin A structure and function differential modulation of actin-binding protein function by latrunculin A, J. Biol. Chem, vol.275, pp.28120-28127, 2000. ,
Structural basis of thymosinbeta4/profilin exchange leading to actin filament polymerization, Proc. Natl. Acad. Sci. USA, vol.111, pp.4596-4605, 2014. ,
DNA repair dysregulation from cancer driver to therapeutic target, Nat. Rev. Cancer, vol.12, p.801, 2012. ,
Platinum-DNA adduct, nucleotide excision repair and platinum based anti-cancer chemotherapy, Cancer Treat. Rev, vol.24, pp.331-344, 1998. ,
DNA repair: dynamic defenders against cancer and aging, PLoS Biol, vol.4, p.203, 2006. ,
Toxicity of jasplakinolide (NSC 613009) in rat and dogs, Proc. Am. Assoc. Cancer Res, vol.39, p.597, 1998. ,
Effects of cytochalasin congeners, microtubule-directed agents, and doxorubicin alone or in combination against human ovarian carcinoma cell lines in vitro, BMC Cancer, vol.15, p.632, 2015. ,
Chemotherapy with cytochalasin congeners in vitro and in vivo against murine models, Invest. New Drugs, vol.33, pp.290-299, 2015. ,