Unconventional immune-related phenomena observed using 18F-FDG PET/CT in Hodgkin lymphoma treated with anti PD-1 monoclonal antibodies

Laurent Dercle; Fatima-Zohra Mokrane; Jean Marc Schiano de Colella; Apasia Stamatoullas; Franck Morschhauser; Pauline Brice; Hervé Ghesquières; Olivier Casasnovas; Aiping Chen; Guillaume Manson; Roch Houot

Unconventional immune-related phenomena observed using 18F-FDG PET/CT in Hodgkin lymphoma treated with anti PD-1 monoclonal antibodies

Laurent Dercle ^{1, 2, *} Fatima-Zohra Mokrane ^{2, 3} Jean Marc Schiano de Colella ⁴ Apasia Stamatoullas ⁵ Franck Morschhauser ⁶ Pauline Brice ⁷ Hervé Ghesquières ⁸ Olivier Casasnovas ⁹ Aiping Chen ¹⁰ Guillaume Manson ^{11, 12} Roch Houot ^{11, 12}

* Corresponding author

1 UMR 1015 - Immunologie des tumeurs et immunothérapie

2 CUMC - Columbia University Medical Center

3 Hôpital de Rangueil

4 Institut Paoli-Calmettes

5 CLCC Henri Becquerel - Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen

6 GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA)-EA 7365

7 Service d'Hémato-oncologie [CHU Saint-Louis]

8 Hôpital Edouard Herriot [CHU - HCL]

9 Service d'Hématologie Clinique (CHU de Dijon)

10 Nanjing Medical University

11 CHU Pontchaillou [Rennes]

12 MICMAC - Microenvironment, Cell Differentiation, Immunology and Cancer

Abstract : The paradigm of response in Hodgkin lymphoma (HL) was developed in cytotoxic chemotherapies and its use as a reference model for immune-modulatory regimens, which restores the immune system's anti-tumor capacity, is questioned.

Keywords : computed tomography Hodgkin lymphoma anti PD-1 pembrolizumab Nivolumab PET/CT 18F-FDG PET

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Cancer

Life Sciences [q-bio] / Human health and pathology / Hematology

Life Sciences [q-bio] / Immunology / Immunotherapy

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https://hal-univ-rennes1.archives-ouvertes.fr/hal-02119287
Contributor : Xavier Chard-Hutchinson <>
Submitted on : Friday, June 14, 2019 - 3:36:37 PM
Last modification on : Thursday, June 27, 2019 - 1:05:16 PM

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