Power behind the throne: A clinical trial simulation study evaluating the impact of controllable design factors on the power of antidepressant trials

Astrid Chevance (1) , Florian Naudet (2, 3) , Raphaël Gaillard (4) , Philippe Ravaud (5, 1) , Raphaël Porcher (1)

1 CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
2 Stanford University
3 CIC - Centre d'Investigation Clinique [Rennes]
4 U894 / UMS 1266 - Institut de psychiatrie et neurosciences
5 Columbia University [New York]

Keywords: modeling; depression; methodology; clinical trials; antidepressants

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Human health and pathology; Psychiatrics and mental health

Astrid Chevance, Florian Naudet, Raphaël Gaillard, Philippe Ravaud, Raphaël Porcher. Power behind the throne: A clinical trial simulation study evaluating the impact of controllable design factors on the power of antidepressant trials. International Journal of Methods in Psychiatric Research, 2019, 28 (3), pp.e1779. ⟨10.1002/mpr.1779⟩. ⟨hal-02120673⟩