Management of epithelial cancer of the ovary, fallopian tube, primary peritoneum. Long text of the joint French clinical practice guidelines issued by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY, endorsed by INCa. (Part 2 systemic, intraperitoneal treatment, elderly patients, fertility preservation, follow-up)

V Lavoue (1) , C Huchon (2) , C Akladios (3) , P Alfonsi (4) , N Bakrin (5) , M Ballester (6) , S Bendifallah (7) , P A Bolze (5) , Fabrice Bonnet (7, 8) , C Bourgin (5) , N Chabbert-Buffet (7) , P Collinet (9) , Blandine Courbiere (10) , T de La Motte Rouge (11) , M Devouassoux-Shisheboran (12) , C Falandry (12) , G Ferron (13) , L Fournier (14) , L Gladieff (13) , F Golfier (5) , S Gouy (15) , F Guyon (16) , E Lambaudie (17) , A Leary (18, 19) , F Lecuru (14) , M A Lefrere-Belda (14) , E Leblanc (20) , A Lemoine (7) , F Narducci (20) , Lobna Ouldamer (21) , P Pautier (18, 19) , F Planchamp (16) , N Pouget (22) , I Ray-Coquard (23) , C Rousset-Jablonski (23) , C Senechal-Davin (16) , C Touboul (24) , I Thomassin-Naggara (7) , C Uzan (25) , B You (26) , E Daraï (7)

1 COSS - Chemistry, Oncogenesis, Stress and Signaling
2 Service de gynécologie et obstétrique [CHI Poissy-Saint Germain]
3 CHU Strasbourg
4 Hôpital Saint-Luc-Saint-Joseph, service anesthésie-réanimation
5 Service d’Urologie [CHU Lyon Sud]
6 Groupe Hospitalier Diaconesses Croix Saint-Simon
7 CHU Tenon [AP-HP]
8 BPH - Bordeaux population health
9 Hôpital Jeanne de Flandres, CHRU de Lille,
10 IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale
11 CRLCC - Centre Eugène Marquis
12 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
13 Institut Claudius Regaud
14 HEGP - Hôpital Européen Georges Pompidou [APHP]
15 Département de chirurgie gynécologique [Gustave Roussy]
16 Institut Bergonié [Bordeaux]
17 Institut Paoli-Calmettes
18 IGR - Institut Gustave Roussy
19 Oncologie gynécologique
20 UNICANCER/Lille - Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille]
21 Département d’Hématologie Clinique [CHU Tours]
22 Institut Curie [Paris]
23 Centre Léon Bérard [Lyon]
24 CHIC - Centre Hospitalier Intercommunal de Créteil
25 CRSA - Centre de Recherche Saint-Antoine
26 HCL - Hospices Civils de Lyon

Adjuvant chemotherapy by carboplatin and paclitaxel is recommended for all high-grade ovarian and tubal cancers (FIGO stages I-IIA) (grade A). After primary surgery is complete, 6 cycles of intravenous chemotherapy (grade A) are recommended, or a discussion with the patient about intraperitoneal chemotherapy, according to her risk-benefit ratio. After complete interval surgery for FIGO stage III, hyperthermic intraperitoneal chemotherapy (HIPEC) can be proposed, in accordance with the modalities of the OV-HIPEC trial (grade B). In cases of postoperative tumor residue or in FIGO stage IV tumors, chemotherapy associated with bevacizumab is recommended (grade A).

Keywords: Tubal cancer; Primary peritoneal cancer; Guidelines; Chemotherapy; Ovarian cancer; Surgery

Domains: Life Sciences [q-bio]; Cancer

V Lavoue, C Huchon, C Akladios, P Alfonsi, N Bakrin, et al.. Management of epithelial cancer of the ovary, fallopian tube, primary peritoneum. Long text of the joint French clinical practice guidelines issued by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY, endorsed by INCa. (Part 2 systemic, intraperitoneal treatment, elderly patients, fertility preservation, follow-up). Journal of Gynecology Obstetrics and Human Reproduction, 2019, 48 (6), pp.379-386. ⟨10.1016/j.jogoh.2019.03.018⟩. ⟨hal-02121103⟩