The potential diagnostic and prognostic role of extracellular vesicles in glioma: current status and future perspectives - Archive ouverte HAL Access content directly
Journal Articles Acta Oncologica Year : 2019

The potential diagnostic and prognostic role of extracellular vesicles in glioma: current status and future perspectives

(1) , (2, 3) , (4) , (1)
1
2
3
4

Abstract

Lack of appropriate diagnostic/prognostic tools for Glioblastoma (GB) is considered one of the major setbacks in the early diagnosis and treatment of this deadly brain tumor. The current gold standard for its diagnosis and staging still relies on invasive biopsy followed by histological examination as well as molecular profiling. Nevertheless, non-invasive approaches are being explored and one example is through the investigation of extracellular vesicles (EVs) in the biofluids of GB patients. EVs are known to carry molecular cargoes such as DNA, mRNA, miRNA, proteins and lipids in almost every type of body fluids. Thus, molecular signature of GB may be present in the EVs derived from these patients. This review focuses on the diagnostic/prognostic potential of EVs in GB, through presenting recent studies on (i) molecular components of EVs, (ii) links between EVs and GB tumor microenvironment, and (iii) clinical potential of EV biomarkers, together with the technical shortcomings researchers need to consider for future studies.
Fichier principal
Vignette du fichier
Azam-2019-The potential diagnostic and prognostic role of extracellular vesicles.pdf (264.93 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-02127312 , version 1 (13-05-2019)

Identifiers

Cite

Zulfikar Azam, Véronique Quillien, Gang Wang, Shing-Shun Tony To. The potential diagnostic and prognostic role of extracellular vesicles in glioma: current status and future perspectives. Acta Oncologica, 2019, 58 (3), pp.353-362. ⟨10.1080/0284186X.2018.1551621⟩. ⟨hal-02127312⟩
148 View
366 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More