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Journal articles
Ene reactions of 2-borylated α-methylstyrenes a practical route to 4-methylenechromanes and derivatives
Abstract : 4-Methylenechromanes were prepared via a three-step process from 2-borylated -methylstyrenes. This sequence is based on a key glyoxylate-ene reaction catalyzed by scandium(III) triflate. The resulting -hydroxy boronates, which cyclise to seven-membered homologues of benzoxaborole on silica gel, were cleanly oxidized with sodium perborate, then cyclised under Mitsunobu conditions. Additionally, several further functional transformations of 4-methylenechromanes or their precursors were carried out to illustrate the synthetic potential of these intermediates.
Cited literature [93 references]
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02150447
Contributor : Laurent Jonchère <>
Submitted on : Monday, November 18, 2019 - 12:24:47 PM
Last modification on : Friday, July 10, 2020 - 4:24:44 PM
Contributor : Laurent Jonchère <>
Submitted on : Monday, November 18, 2019 - 12:24:47 PM
Last modification on : Friday, July 10, 2020 - 4:24:44 PM
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Ene reactions of 2-borylated-m...
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