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Pregnancies and obstetrical prognosis after oocyte donation in Turner Syndrome A multicentric study

Abstract : Introduction - Turner syndrome is one of the most frequent chromosomal abnormalities in women, with a prevalence estimated to be 1 of 2500 live birth. Pregnancy in women with Turner syndrome is known to be at high risk, whether it is spontaneous or after oocyte donation, because of miscarriages and potential cardio-vascular complications which can be life-threatening. All of these patients should therefore be screened with a comprehensive cardio-vascular assessment before pregnancy, and have a close follow-up during and after pregnancy.Patients and methods - It is a retrospective study, conducted in 10 of the 27 French oocyte donation centers between 2012 and 2016, on all the patients presenting with Turner syndrome included in an oocyte donation program.Results - 151 embryo transfers were realized in 73 patients, resulting in 39 pregnancies. Among these pregnancies, 24 children were born healthy, 11 spontaneous miscarriages, 3 voluntary abortions, 1 extra-uterine pregnancy and 1 maternal death from non-cardio-vascular origin occurred. Pregnancies were complicated by gravid arterial hypertension in 28.2% of cases, preeclampsia in 10.3% of cases, and gestational diabetes in 7.7% of cases.Conclusion - This study bring out obstetrical complications of the same magnitude than the ones described in the literature. Lead over a period of 4 years, in 10 French oocyte donation centers, it doesn't reveal any cardio-vascular complications, conversely to other studies published before French and American recommendations. This study reinforces the usefulness of specific recommendations for the care of these particular patients.
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Submitted on : Monday, July 1, 2019 - 3:38:04 PM
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Andre et al-2019-Pregnancies a...
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Hélène Andre, Celine Pimentel, Segolene Veau, Mathilde Domin-Bernhard, Hélène Letur-Konirsch, et al.. Pregnancies and obstetrical prognosis after oocyte donation in Turner Syndrome A multicentric study. European Journal of Obstetrics & Gynecology and Reproductive Biology, Elsevier, 2019, 238, pp.73-77. ⟨10.1016/j.ejogrb.2019.05.012⟩. ⟨hal-02153621⟩



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