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CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule

Abstract : CD90 is a membrane GPI-anchored protein with one Ig V-type superfamily domain that was initially described in mouse T cells. Besides the specific expression pattern and functions of CD90 that were described in normal tissues, i.e., neurons, fibroblasts and T cells, increasing evidences are currently highlighting the possible involvement of CD90 in cancer. This review first provides a brief overview on CD90 gene, mRNA and protein features and then describes the established links between CD90 and cancer. Finally, we report newly uncovered functional connections between CD90 and endoplasmic reticulum (ER) stress signaling and discuss their potential impact on cancer development.
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Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Friday, July 10, 2020 - 2:54:03 PM
Last modification on : Friday, February 19, 2021 - 3:04:56 PM
Long-term archiving on: : Monday, November 30, 2020 - 8:22:14 PM


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Chloe Sauzay, Konstantinos Voutetakis, Aristotelis Chatziioannou, Eric Chevet, Tony Avril. CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule. Frontiers in Cell and Developmental Biology, Frontiers media, 2019, 7, pp.66. ⟨10.3389/fcell.2019.00066⟩. ⟨hal-02156139⟩



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