CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Frontiers in Cell and Developmental Biology Année : 2019

CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule

Résumé

CD90 is a membrane GPI-anchored protein with one Ig V-type superfamily domain that was initially described in mouse T cells. Besides the specific expression pattern and functions of CD90 that were described in normal tissues, i.e., neurons, fibroblasts and T cells, increasing evidences are currently highlighting the possible involvement of CD90 in cancer. This review first provides a brief overview on CD90 gene, mRNA and protein features and then describes the established links between CD90 and cancer. Finally, we report newly uncovered functional connections between CD90 and endoplasmic reticulum (ER) stress signaling and discuss their potential impact on cancer development.
Fichier principal
Vignette du fichier
pdf (3.92 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-02156139 , version 1 (10-07-2020)

Identifiants

Citer

Chloe Sauzay, Konstantinos Voutetakis, Aristotelis Chatziioannou, Eric Chevet, Tony Avril. CD90/Thy-1, a Cancer-Associated Cell Surface Signaling Molecule. Frontiers in Cell and Developmental Biology, 2019, 7, pp.66. ⟨10.3389/fcell.2019.00066⟩. ⟨hal-02156139⟩
70 Consultations
42 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More