Synthesis and biological studies of new quinazolines with ether functions in position 2

D. Brahmaiah; A.K.D. Bhavani; P. Aparna; N.S. Kumar; H. Solhi; Ronan Le Guével; B. Baratte; S. Ruchaud; S. Bach; Paul Mosset; R. Grée

doi:10.24820/ark.5550190.p010.859

Journal articles

Synthesis and biological studies of new quinazolines with ether functions in position 2

D. Brahmaiah ¹ A.K.D. Bhavani ² P. Aparna N.S. Kumar H. Solhi ³ Ronan Le Guével ³ B. Baratte ⁴ S. Ruchaud ⁴ S. Bach ⁴ Paul Mosset ⁵ R. Grée ⁵

1 JNU - Jawaharlal Nehru University

2 Osmania University

3 ImPACcell - Plate-forme ImPACcell

4 SBR - Station biologique de Roscoff

5 ISCR - Institut des Sciences Chimiques de Rennes

Abstract : A series of new quinazolines linked to triazoles through an ether chain in position 2 has been designed and synthetized through a flexible route. Cytotoxicity assays on selected cancer cell lines and inhibition studies toward a panel of representative mammalian kinases have been performed on these molecules.

Keywords : Kinases Cytotoxicity Quinazolines Triazoles

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Journal articles

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Chemical Sciences / Medicinal Chemistry

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