, 27 (CH2), 56.24 (CH3, OMe on quinazoline), 55.64 (CH3, OMe of 3-methoxyphenyl), CH, C6 of 3-methoxyphenyl), vol.106

. Hrms-esi,

, 3-triazol-4-yl)methoxy)-8-methoxyquinazoline (11f):. Reaction of 15 (25 mg, 0.11 mmol) with 16f (23.1 mg, 0.11 mmol) gave 11f: 31 mg, 64% yield. mp 144-146 °C; FT-IR (KBr, J 0.6 Hz, 1H, H-triazole), 7.67-7.60 (symmetrical m, 4H of 4-bromophenyl), 7.47 (dd, J 8.1, 1.4 Hz, 1H, H-C7 of quinazoline), 7.42 (dd, J 8.1, 7.5 Hz, 1H, H-C6 of quinazoline), vol.2, p.3061, 1024.

. Hrms-esi,

, -phenyl-1H-1,2,3-triazol-4-yl)methoxy)quinazoline (11g)

, 11 mmol) with 16g (13.90 mg, 0.11 mmol) gave 11g: 29.1 mg, 74% yield. mp 168-170 °C; FT-IR (KBr, cm -1 ): 3143, 3070, vol.764, 1030.

2. Mhz, . Ph-;-m,-2h, H. Ph-;-m,-3h, H. Of-quinazoline, H. Of-quinazoline et al., 82 (s, 2H, CH2), 4.10 (s, 3H, CH3, OMe). 13 C NMR (75 MHz, CDCl3): ? 163.74 (CH, ? to N of quinazoline), 161.64 (C, C2 of quinazoline), 153.83 (C, C8 of quinazoline), 144.40 (C of triazole), 143.57 (C, C8a of quinazoline), 137.20 (C ipso of Ph), 129.74 (2CH, meta of Ph), 128.69 (CH, para of Ph), 125.30 (CH, C6 of quinazoline), vol.7

. Hrms-esi, Reaction of 15 (20 mg, 0.093 mmol) with 16h (12.38 mg, 0.093 mmol) gave 11h: 24.2 mg, 74% yield. mp 109-111 °C; FT-IR (KBr, cm -1 ): 3006, 1579, C7 of quinazoline), 7.39 (dd, J 8.1, 7.5 Hz, 1H, H-C6 of quinazoline), 7.37-7.32 (m, 3H, 2H meta and 1H para of benzyl, vol.2, 1002.

1. Hz and H. Of-quinazoline-;-s,-2h, 13 C NMR (75 MHz, CDCl3): ? 163.63 (CH, ? to N of quinazoline), 161.52 (C, C2 of quinazoline), 153.71 (C, C8 of quinazoline), 144.07 (C of triazole), 143.49 (C, C8a of quinazoline, CH of triazole), 122.77 (C, C4a of quinazoline), 118.89 (CH, C7 of quinazoline), vol.5

. Hrms-esi,

, DMSO-d6): ? final volume of 6 µl for 30 min at 30°C in the following buffer: 10 mM MgCl2, 1 mM EGTA, 1 mM DTT, 25 mM Tris-HCl pH 7.5, 50 µg/ml heparin; with either protein or peptide as substrate in the presence of 10 µM ATP. After stopping the kinase reaction, Kinase Detection Reagent was added for one hour at RT. The transmitted signal was then measured using an Envision microplate luminometer (PerkinElmer, Waltham, MA) and expressed in Relative Light Unit (RLU). HsCDK5/p25 (human, recombinant, expressed in bacteria) was assayed on 0.8 µg/µl of histone H1 as substrate. HsCDK9/CyclinT (human, recombinant, 1H-1,2,3-triazol-4-yl)methoxy)quinazoline (11i). Reaction of 15 (20 mg, 0.093 mmol) with 16i (16.56 mg, 0.093 mmol) gave 11i: 18.4 mg, 50% yield. mp 179-181 °C; FT-IR (KBr, vol.3008, p.3132, 1016.

, HsCK1? (human, recombinant, expressed by baculovirus in Sf9 insect cells) was assayed on 0.022 µg/µl of the following peptide: RRKHAAIGSpAYSITA ("Sp" stands for phosphorylated serine) as CK1-specific substrate. RnDYRK1A-kd (Rattus norvegicus, kinase domain aa 1 to 499, expressed in bacteria, DNA vector kindly provided by, Sf9 insect cells) was assayed on 0

. Mmclk1, HsPim-1 (human proto-oncogene, recombinant, expressed in bacteria) was assayed on 0.8 µg/µl of histone H1 (Sigma #H5505) as substrate. HsHaspin-kd (human, kinase domain, amino acids 470 to 798, recombinant, expressed in bacteria) was assayed on 0.007 µg/µl of Histone H3 (1-21) peptide (ARTKQTARKSTGGKAPRKQLA) as substrate, Mus musculus, recombinant, expressed in bacteria) was assayed on 0.027 ?g/µl of the following peptide: GRSRSRSRSRSR as substrate

J. P. Michael, Nat. Prod. Rep, vol.24, pp.223-246, 2007.

I. Khan, A. Ibrar, W. Ahmed, and A. Saeed, Eur. J. Med. Chem, vol.90, pp.124-169, 2015.

O. O. Ajani, O. Y. Audu, D. V. Aderohunmu, F. E. Owalabi, and A. O. Olomieja, Am. J. Drug Disc. Dev, vol.7, pp.1-24, 2017.

H. Ji, H. Dan, and G. Rao, Heterocycl. Commun, vol.24, pp.1-10, 2018.

D. Dheer, V. Singh, and R. Shankar, Bioorg. Chem, vol.71, pp.30-54, 2017.

Y. Yamamoto and I. Shinkai, Science of Synthesis, Thieme Chemistry: Georg Thieme Verlag KG 2004, 2 Hetarenes, Kikelj D. Product class 13: Quinazolines pp, pp.573-749

R. A. Aitken, Science of Synthesis: Knowledge Updates, Quinazolines, issue.2, 2015.

H. C. Kolb, M. G. Finn, K. B. Sharpless, and . Angw, Chem. Int. Ed, vol.40, 2001.

V. V. Rostovtsev, L. G. Green, K. B. Sharpless, and . Ang, Chem. Int. Ed, vol.41, pp.2596-2599, 2002.

C. W. Tornoe, C. Christensen, and M. Medal, J. Org. Chem, vol.67, pp.3057-3064, 2002.

J. Lutz, Ang. Chem. Int. Ed, vol.47, pp.2182-2184, 2008.

J. E. Klein, M. S. Holzwarth, S. Hohloch, B. Sarkar, and B. Plietker, Eur. J. Org. Chem, vol.28, pp.6310-6316, 2013.