Skip to Main content Skip to Navigation
Journal articles

CD95/Fas and metastatic disease: What does not kill you makes you stronger

Abstract : CD95 (also known as Fas) is the prototype of death receptors; however, evidence suggests that this receptor mainly implements non-apoptotic signaling pathways such as NF-κB, MAPK, and PI3K that are involved in cell migration, differentiation, survival, and cytokine secretion. At least two different forms of CD95 L exist. The multi-aggregated transmembrane ligand (m-CD95 L) is cleaved by metalloproteases to release a homotrimeric soluble ligand (s-CD95 L). Unlike m-CD95 L, the interaction between s-CD95 L and its receptor CD95 fails to trigger apoptosis, but instead promotes calcium-dependent cell migration, which contributes to the accumulation of inflammatory Th17 cells in damaged organs of lupus patients and favors cancer cell invasiveness. Novel inhibitors targeting the pro-inflammatory roles of CD95/CD95 L may provide attractive therapeutic options for patients with chronic inflammatory disorders or cancer. This review discusses the roles of the CD95/CD95 L pair in cell migration and metastasis.
Complete list of metadatas

Cited literature [153 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-02179928
Contributor : Laurent Jonchère <>
Submitted on : Thursday, September 12, 2019 - 4:44:37 PM
Last modification on : Thursday, March 12, 2020 - 9:57:24 AM
Document(s) archivé(s) le : Saturday, February 8, 2020 - 6:51:33 AM

File

Legembre_et al_CD95 Fas and me...
Files produced by the author(s)

Identifiers

Citation

Jean Philippe Guégan, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Thomas Ducret, Jean-François Quignard, et al.. CD95/Fas and metastatic disease: What does not kill you makes you stronger. Seminars in Cancer Biology, Elsevier, 2020, 60, pp.121-131. ⟨10.1016/j.semcancer.2019.06.004⟩. ⟨hal-02179928⟩

Share

Metrics

Record views

138

Files downloads

136