Catalytically Active Species in Copper/DiPPAM-Catalyzed 1,6-Asymmetric Conjugate Addition of Dialkylzinc to Dienones A Computational Overview

Stéphanie Halbert (1) , Jimmy Lauberteaux (2) , Charlie Blons (3) , Renata Marcia de Figueiredo (2) , Christophe Crévisy (3) , Olivier Baslé (3) , Jean-Marc Campagne (2) , Marc Mauduit (3) , Hélène Gérard (4)

1 LCT - Laboratoire de chimie théorique
2 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
3 ISCR - Institut des Sciences Chimiques de Rennes
4 SU - Sorbonne Université

Four different catalytically active species are computationally examined in order to investigate the mechanism of Cu/DiPPAM-catalyzed 1,6-conjugate addition of dialkylzinc to acyclic dienones. A DiPPAM-bridged Cu(alkyl)-Zn(acetate) bimetallic complex exhibits the best catalytic activity, which can be associated with the best balance between the stability of the dienone adduct and its activation by copper. The selectivities (regio- and enantioselectivity) associated with the retained mechanism are investigated by DFT calculations and successfully compared to experimental data, including the critical influence of the substituents within the dienone on the regioselectivity and the obtained enantioselectivity for the formation of one 1,6-adduct.

Keywords: catalysis; Cu/Zn heterobimetallic active species; C−C bond; DFT; enantioselectivity

Domains: Chemical Sciences

Stéphanie Halbert, Jimmy Lauberteaux, Charlie Blons, Renata Marcia de Figueiredo, Christophe Crévisy, et al.. Catalytically Active Species in Copper/DiPPAM-Catalyzed 1,6-Asymmetric Conjugate Addition of Dialkylzinc to Dienones A Computational Overview. ChemCatChem, 2019, 11 (16), pp.4108-4115. ⟨10.1002/cctc.201900233⟩. ⟨hal-02181830⟩