Acyl-Imidazoles A Privileged Ester Surrogate for Enantioselective Synthesis

Abstract : Since the first report by Evans in asymmetric Friedel-Crafts reactions, the use of acyl-imidazoles has blossomed as powerful ester/amide surrogates. The imidazole scaffold indeed displays stability and special activation features allowing both better reactivity and selectivity in traditional ester/amide functionalizations α-(enolate chemistry), β-(conjugate additions), α,β-(cycloadditions) or γ/δ-(vinylogous). An overview of the contemporary and growing interest in acyl-imidazoles in metal- and organo-catalyzed transformations (bio-hybrid catalytic systems will be fully described in a back-to-back Minireview) will be highlighted. Moreover, post-functionalization expediencies are also going to be discussed in this Minireview. © 2019 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim
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Submitted on : Friday, July 12, 2019 - 2:05:11 PM
Last modification on : Saturday, July 13, 2019 - 1:25:17 AM

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J. Lauberteaux, D. Pichon, O. Baslé, M. Mauduit, R. Marcia de Figueiredo, et al.. Acyl-Imidazoles A Privileged Ester Surrogate for Enantioselective Synthesis. ChemCatChem, 2019, ⟨10.1002/cctc.201900754⟩. ⟨hal-02181832⟩

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