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Acyl-Imidazoles A Privileged Ester Surrogate for Enantioselective Synthesis

Abstract : Since the first report by Evans in asymmetric Friedel‐Crafts reactions, the use of acyl‐imidazoles has blossomed as powerful ester/amide surrogates. The imidazole scaffold indeed displays stability and special activation features allowing both better reactivity and selectivity in traditional ester/amide functionalizations: α‐(enolate chemistry), β‐(conjugate additions), α,β‐(cycloadditions) or γ/δ‐(vinylogous). An overview of the contemporary and growing interest in acyl‐imidazoles in metal‐ and organo‐catalyzed transformations (bio‐hybrid catalytic systems will be fully described in a back‐to‐back Minireview) will be highlighted. Moreover, post‐functionalization expediencies are also going to be discussed in this Minireview.
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Submitted on : Thursday, November 7, 2019 - 12:38:54 PM
Last modification on : Friday, July 10, 2020 - 4:19:35 PM
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J. Lauberteaux, D. Pichon, O. Baslé, M. Mauduit, R. Marcia de Figueiredo, et al.. Acyl-Imidazoles A Privileged Ester Surrogate for Enantioselective Synthesis. ChemCatChem, Wiley, 2019, 11 (23), pp.5705-5722. ⟨10.1002/cctc.201900754⟩. ⟨hal-02181832⟩

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