Trends in sodium valproate prescriptions among children aged 0 to 14 years between 2010 and 2016 A study based on the French National Health Insurance Database - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Seizure - European Journal of Epilepsy Année : 2019

Trends in sodium valproate prescriptions among children aged 0 to 14 years between 2010 and 2016 A study based on the French National Health Insurance Database

Résumé

PURPOSE: After a huge campaign of information on the teratogenic risk of sodium valproate (VPA) having taken place in France we aimed to evaluate the trend of its prescriptions in young epileptic girls.METHOD: Using the French National Health Insurance Database we searched for patients aged 0-14 years being supplied an antiepileptic drug (AED) between 2010 and 2016.RESULTS: 113,362 children received at least one AED, 61,259 boys and 52,103 girls. Compared to 2010-2014 years, VPA was less prescribed in 2016 as first AED (29% vs 37.3% respectively). The difference between the two periods was greater for girls (-41%) than for boys (-12%).CONCLUSION: The changing trend of VPA as first AED prescribed, particularly in girls, reflects published evidence in terms of safety.
Fichier principal
Vignette du fichier
Polard-2019-Trends in sodium valproate prescriptions among children.pdf (1.13 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02277189 , version 1 (09-09-2019)

Identifiants

Citer

Elisabeth Polard, Adeline Degremont, Caroline Rault, Béranger Le Nautout, Emmanuel Oger, et al.. Trends in sodium valproate prescriptions among children aged 0 to 14 years between 2010 and 2016 A study based on the French National Health Insurance Database. Seizure - European Journal of Epilepsy, 2019, 70, pp.71-76. ⟨10.1016/j.seizure.2019.07.007⟩. ⟨hal-02277189⟩
133 Consultations
137 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More