Trends in sodium valproate prescriptions among children aged 0 to 14 years between 2010 and 2016 A study based on the French National Health Insurance Database - Archive ouverte HAL Access content directly
Journal Articles Seizure - European Journal of Epilepsy Year : 2019

Trends in sodium valproate prescriptions among children aged 0 to 14 years between 2010 and 2016 A study based on the French National Health Insurance Database

Abstract

PURPOSE: After a huge campaign of information on the teratogenic risk of sodium valproate (VPA) having taken place in France we aimed to evaluate the trend of its prescriptions in young epileptic girls.METHOD: Using the French National Health Insurance Database we searched for patients aged 0-14 years being supplied an antiepileptic drug (AED) between 2010 and 2016.RESULTS: 113,362 children received at least one AED, 61,259 boys and 52,103 girls. Compared to 2010-2014 years, VPA was less prescribed in 2016 as first AED (29% vs 37.3% respectively). The difference between the two periods was greater for girls (-41%) than for boys (-12%).CONCLUSION: The changing trend of VPA as first AED prescribed, particularly in girls, reflects published evidence in terms of safety.
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hal-02277189 , version 1 (09-09-2019)

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Elisabeth Polard, Adeline Degremont, Caroline Rault, Béranger Le Nautout, Emmanuel Oger, et al.. Trends in sodium valproate prescriptions among children aged 0 to 14 years between 2010 and 2016 A study based on the French National Health Insurance Database. Seizure - European Journal of Epilepsy, 2019, 70, pp.71-76. ⟨10.1016/j.seizure.2019.07.007⟩. ⟨hal-02277189⟩
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