Asymmetric synthesis of hetero-1,2,3,4,5-pentasubstituted ferrocenes

William Erb (1) , Thierry Roisnel (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

The first synthesis of enantioenriched ferrocenes bearing five different substituents on the same cyclopentadienyl ring is described through an unprecedented asymmetric halogen 'dance' reaction. This work not only extends the chemistry of fluoroferrocene derivatives and constitutes the very first entry into the world of enantioenriched hetero-pentasubstituted ferrocenes, it also lays the foundation for research in other metallocene families.

Domaines: Chimie de coordination

William Erb, Thierry Roisnel. Asymmetric synthesis of hetero-1,2,3,4,5-pentasubstituted ferrocenes. Chemical Communications, 2019, 55 (62), pp.9132-9135. ⟨10.1039/c9cc04604f⟩. ⟨hal-02278407⟩