Impact of a targeted monitoring on data-quality and data-management workload of randomized controlled trials a prospective comparative study

Claire Fougerou-Leurent (1, 2) , Bruno Laviolle (2, 1) , Christelle Tual (2, 1) , Valérie Visseiche (1) , Aurelie Veislinger (2, 1) , Hélène Danjou (2, 1) , Amélie Martin (2, 1) , Valérie Turmel (2, 1) , Alain Renault (2) , Eric Bellissant (2, 1)

1 CHU Pontchaillou [Rennes]
2 CIC - Centre d'Investigation Clinique [Rennes]

Aims: Monitoring risk‐based approaches in clinical trials are encouraged by regulatory guidance. However, the impact of a targeted source data verification (SDV) on data‐management (DM) workload and on final data quality needs to be addressed.Methods: MONITORING was a prospective study aiming at comparing full SDV (100% of data verified for all patients) and targeted SDV (only key data verified for all patients) followed by the same DM program (detecting missing data and checking consistency) on final data quality, global workload and staffing costs.Results: In all, 137,008 data including 18,124 key data were collected for 126 patients from six clinical trials. Compared to the final database obtained using the full SDV monitoring process, the final database obtained using the targeted SDV monitoring process had a residual error rate of 1.47% [95% confidence interval, 1.41% to 1.53%] on overall data and 0.78% [95% confidence interval, 0.65% to 0.91%] on key data. There were nearly four times more queries per study with targeted SDV than with full SDV (mean±SD: 132±101 vs 34±26; p=0.03). For a handling time of 15 min per query, the global workload of the targeted SDV monitoring strategy remained below that of the full SDV monitoring strategy. From 25 minutes per query, it was above increasing progressively to represent a 50% increase for 45 minutes per query.Conclusion: Targeted SDV monitoring is accompanied by increased workload for DM, which allows to obtain a small proportion of remaining errors on key data (<1%), but may substantially increase trial costs.

Keywords: targeted monitoring; randomized clinical trial; data management; risk-based monitoring; source data verification

Domains: Life Sciences [q-bio]; Pharmaceutical sciences; Life Sciences [q-bio]; Santé publique et épidémiologie

Claire Fougerou-Leurent, Bruno Laviolle, Christelle Tual, Valérie Visseiche, Aurelie Veislinger, et al.. Impact of a targeted monitoring on data-quality and data-management workload of randomized controlled trials a prospective comparative study. British Journal of Clinical Pharmacology, 2019, 85 (12), pp.2784-2792. ⟨10.1111/bcp.14108⟩. ⟨hal-02280495⟩