Skip to Main content Skip to Navigation
Journal articles

Enhanced cell-cell contact stability and decreased N-cadherin-mediated migration upon fibroblast growth factor receptor-N-cadherin cross talk

Abstract : N-cadherin adhesion has been reported to enhance cancer and neuronal cell migration either by mediating actomyosin-based force transduction or initiating fibroblast growth factor receptor (FGFR)-dependent biochemical signalling. Here we show that FGFR1 reduces N-cadherin-mediated cell migration. Both proteins are co-stabilised at cell–cell contacts through direct interaction. As a consequence, cell adhesion is strengthened, limiting the migration of cells on N-cadherin. Both the inhibition of migration and the stabilisation of cell adhesions require the FGFR activity stimulated by N-cadherin engagement. FGFR1 stabilises N-cadherin at the cell membrane through a pathway involving Src and p120. Moreover, FGFR1 stimulates the anchoring of N-cadherin to actin. We found that the migratory behaviour of cells depends on an optimum balance between FGFR-regulated N-cadherin adhesion and actin dynamics. Based on these findings we propose a positive feed-back loop between N-cadherin and FGFR at adhesion sites limiting N-cadherin-based single-cell migration.
Complete list of metadatas

Cited literature [42 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-02280594
Contributor : Laurent Jonchère <>
Submitted on : Monday, February 3, 2020 - 4:59:14 PM
Last modification on : Friday, April 10, 2020 - 4:57:21 PM
Long-term archiving on: : Monday, May 4, 2020 - 5:14:04 PM

File

Nguyen-2019-Enhanced cell–ce...
Files produced by the author(s)

Identifiers

Citation

Thao Nguyen, Laurence Duchesne, Gautham Hari Narayana Sankara Narayana, Nicole Boggetto, David D Fernig, et al.. Enhanced cell-cell contact stability and decreased N-cadherin-mediated migration upon fibroblast growth factor receptor-N-cadherin cross talk. Oncogene, Nature Publishing Group, 2019, 38 (35), pp.6283-6300. ⟨10.1038/s41388-019-0875-6⟩. ⟨hal-02280594⟩

Share

Metrics

Record views

315

Files downloads

872