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Lichen butyrolactone derivatives disrupt oral bacterial membrane

Abstract : We have previously demonstrated that out of the butyrolactones series synthesized based on the natural lichen metabolite lichesterinic acid, compound (B-13) was the most effective against oral bacteria. However, its antibacterial mechanism is still unknown. In this study, we have investigated its bacterial localization by synthesizing a fluorescently labeled B-13 with NBD while maintaining its antibacterial activity. We showed that this compound binds to Streptococcus gordonii cell surface, as demonstrated by HPLC analysis. By adhering to cell surface, B-13 induced cell wall disruption leading to the release of bacterial constituents and consequently, the death of S. gordonii, a Gram-positive bacterium. A Gram-negative counterpart, Porphyromanas gingivalis, showed also cracked and ruptured cells in the presence of B-13. Besides, we also demonstrated that the analog of B-13, B-12, has also induced disruption of P. gingivalis and S. gordonii. This study revealed that butyrolactones can be considered as potent antibacterial compounds against oral pathogens causing medical complications.
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Alaa Sweidan, Imen Smida, Marylene Chollet-Krugler, Aurélie Sauvager, Julien Vallet, et al.. Lichen butyrolactone derivatives disrupt oral bacterial membrane. Fitoterapia, Elsevier, 2019, 137, pp.104274. ⟨10.1016/j.fitote.2019.104274⟩. ⟨hal-02280840⟩

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