Rh -Catalyzed P -Directed C-H Bond Alkylation: Design of Multifunctional Phosphines for Carboxylation of Aryl Bromides with Carbon Dioxide

Zhuan Zhang (1) , Thierry Roisnel (1) , Pierre H. Dixneuf (1) , Jean-François Soulé (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

We report the C−H alkylation of biarylphosphines at the ortho′ position(s) with alkenes by using rhodium(I) catalysis, which provides straightforward access to a large library of multifunctionalized phosphines. Some of these modified ligands outperformed commercially available phosphines in the Pd‐catalyzed carboxylation of aryl bromides with carbon dioxide in the presence of a photoredox catalyst.

Mots clés: C−H functionalization; carbon dioxide; alkylation; phosphine ligands; rhodium

Domaines: Chimie

Zhuan Zhang, Thierry Roisnel, Pierre H. Dixneuf, Jean-François Soulé. Rh -Catalyzed P -Directed C-H Bond Alkylation: Design of Multifunctional Phosphines for Carboxylation of Aryl Bromides with Carbon Dioxide. Angewandte Chemie International Edition, 2019, 58 (40), pp.14110-14114. ⟨10.1002/anie.201906913⟩. ⟨hal-02280862⟩