Multi T1-weighted contrast MRI with fluid and white matter suppression at 1.5 T

Jérémy Beaumont; Hervé Saint-Jalmes; Oscar Acosta; Tobias Kober; Mark Tanner; Jean-Christophe Ferré; Olivier Salvado; Jürgen Fripp; Giulio Gambarota

Multi T1-weighted contrast MRI with fluid and white matter suppression at 1.5 T

Jérémy Beaumont ¹ Hervé Saint-Jalmes ¹ Oscar Acosta ¹ Tobias Kober ² Mark Tanner ³ Jean-Christophe Ferré ^{4, 5} Olivier Salvado ⁶ Jürgen Fripp ⁶ Giulio Gambarota ¹

1 LTSI - Laboratoire Traitement du Signal et de l'Image

2 CHUV - Division de cardiologie [CHU Vaudois]

3 Konica Minolta Company [Londres]

4 CHU Pontchaillou [Rennes]

5 Empenn

IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE, Inria Rennes – Bretagne Atlantique , INSERM - Institut National de la Santé et de la Recherche Médicale

6 CSIRO ICT Centre - CSIRO Information and Commuciation Technologies

Abstract : Introduction The fluid and white matter suppression sequence (FLAWS) provides two T1-weighted co-registered datasets a white matter (WM) suppressed contrast (FLAWS1) and a cerebrospinal fluid (CSF) suppressed contrast (FLAWS2). FLAWS has the potential to improve the contrast of the subcortical brain regions that are important for Deep Brain Stimulation surgery planning. However, to date FLAWS has not been optimized for 1.5 T. In this study, the FLAWS sequence was optimized for use at 1.5 T. In addition, the contrast-enhancement properties of FLAWS image combinations were investigated using two voxel-wise FLAWS combined images the division (FLAWS-div) and the high contrast (FLAWS-hc) image. Methods FLAWS sequence parameters were optimized for 1.5 T imaging using an approach based on the use of a profit function under constraints for brain tissue signal and contrast maximization. MR experiments were performed on eleven healthy volunteers (age 18–30). Contrast (CN) and contrast to noise ratio (CNR) between brain tissues were measured in each volunteer. Furthermore, a qualitative assessment was performed to ensure that the separation between the internal globus pallidus (GPi) and the external globus pallidus (GPe) is identifiable in FLAWS1. Results The optimized set of sequence parameters for FLAWS at 1.5 T provided contrasts similar to those obtained in a previous study at 3 T. The separation between the GPi and the GPe was clearly identified in FLAWS1. The CN of FLAWS-hc was higher than that of FLAWS1 and FLAWS2, but was not different from the CN of FLAWS-div. The CNR of FLAWS-hc was higher than that of FLAWS-div. Conclusion Both qualitative and quantitative assessments validated the optimization of the FLAWS sequence at 1.5 T. Quantitative assessments also showed that FLAWS-hc provides an enhanced contrast compared to FLAWS1 and FLAWS2, with a higher CNR than FLAWS-div. © 2019

Keywords : FLAWS Brain Image combination Globus pallidus MRI

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Bioengineering

Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-02281467
Contributor : Laurent Jonchère <>
Submitted on : Monday, September 9, 2019 - 11:31:33 AM
Last modification on : Tuesday, November 19, 2019 - 5:06:02 PM

Multi T1-weighted contrast MRI with fluid and white matter suppression at 1.5 T

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Multi T1-weighted contrast MRI with fluid and white matter suppression at 1.5 T

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Multi T1-weighted contrast MRI with fluid and white matter suppression at 1.5 T