Y. Shi, Y. Wang, and Q. Li, Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases, Nature Reviews Nephrology, vol.14, pp.493-507, 2018.

J. Galipeau and L. Sensebé, Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities, Cell Stem Cell, vol.22, pp.824-833, 2018.

J. Galipeau, The mesenchymal stromal cells dilemma--does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graftversus-host disease represent a death knell or a bump in the road?, Cytotherapy, vol.15, pp.2-8, 2013.

L. Sensebé, P. Bourin, and K. Tarte, Good manufacturing practices production of mesenchymal stem/stromal cells, Human Gene Therapy, vol.22, pp.19-26, 2011.

M. Mendicino, A. M. Bailey, and K. Wonnacott, MSC-based product characterization for clinical trials: an FDA perspective, Cell Stem Cell, vol.14, pp.141-145, 2014.

G. Moll, J. J. Alm, and L. C. Davies, Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?, Stem Cells, vol.32, pp.2430-2442, 2014.

S. Loisel, J. Dulong, and C. Ménard, Brief Report: Proteasomal Indoleamine 2,3-Dioxygenase Degradation Reduces the Immunosuppressive Potential of Clinical Grade-Mesenchymal Stromal Cells Undergoing Replicative Senescence, Stem Cells, vol.35, pp.1431-1436, 2017.

R. Chinnadurai, I. B. Copland, and M. A. Garcia, Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFN? Licensing, Stem Cells, vol.34, pp.2429-2442, 2016.

K. Cho, M. Park, and Y. Kim, RNA sequencing reveals a transcriptomic portrait of human mesenchymal stem cells from bone marrow, adipose tissue, and palatine tonsils, Sci Rep, vol.7, p.17114, 2017.

D. C. De-almeida, M. Ferreira, and J. Franzen, Epigenetic Classification of Human Mesenchymal Stromal Cells, Stem Cell Reports, vol.6, pp.168-175, 2016.

B. Jansen, C. Gilissen, and H. Roelofs, Functional differences between mesenchymal stem cell populations are reflected by their transcriptome, Stem Cells and Development, vol.19, pp.481-490, 2010.

R. Torensma, H. Prins, and E. Schrama, The impact of cell source, culture methodology, culture location, and individual donors on gene expression profiles of bone marrow-derived and adipose-derived stromal cells, Stem Cells and Development, vol.22, pp.1086-1096, 2013.

S. J. Lee, T. Yi, and S. H. Ahn, Comparative study on metabolite level in tissuespecific human mesenchymal stem cells by an ultra-performance liquid chromatography quadrupole time of flight mass spectrometry, Analytica Chimica Acta, vol.1024, pp.112-122, 2018.

A. Reinisch, N. Etchart, and D. Thomas, Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation, Blood, vol.125, pp.249-260, 2015.

P. Mattar and K. Bieback, Comparing the Immunomodulatory Properties of Bone Marrow, Adipose Tissue, and Birth-Associated Tissue Mesenchymal Stromal Cells. Front Immunol, vol.6, p.560, 2015.

C. Ménard and K. Tarte, Immunoregulatory properties of clinical grade mesenchymal stromal cells: evidence, uncertainties, and clinical application, Stem Cell Research & Therapy, vol.4, p.64, 2013.

C. Ménard, L. Pacelli, and G. Bassi, Clinical-grade mesenchymal stromal cells produced under various good manufacturing practice processes differ in their immunomodulatory properties: standardization of immune quality controls, Stem Cells and Development, vol.22, pp.1789-1801, 2013.

S. M. Melief, J. J. Zwaginga, and W. E. Fibbe, Adipose tissue-derived multipotent stromal cells have a higher immunomodulatory capacity than their bone marrowderived counterparts, Stem Cells Translational Medicine, vol.2, pp.455-463, 2013.

A. Ribeiro, P. Laranjeira, and S. Mendes, Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells, Stem Cell Research & Therapy, vol.4, p.125, 2013.

J. Valencia, B. Blanco, and R. Yáñez, Comparative analysis of the immunomodulatory capacities of human bone marrow-and adipose tissuederived mesenchymal stromal cells from the same donor, Cytotherapy, vol.18, pp.1297-1311, 2016.

P. Bourin, J. Peyrafitte, and S. Fleury-cappellesso, A first approach for the production of human adipose tissue-derived stromal cells for therapeutic use, Methods Mol Biol, vol.702, pp.331-343, 2011.

P. Langfelder and S. Horvath, WGCNA: an R package for weighted correlation network analysis, BMC Bioinformatics, vol.9, p.559, 2008.

S. Pandey, F. Mourcin, and T. Marchand, IL-4/CXCL12 loop is a key regulator of lymphoid stroma function in follicular lymphoma, Blood, vol.2017, pp.2016-2024
URL : https://hal.archives-ouvertes.fr/hal-01555850

M. Grégoire, F. Guilloton, and C. Pangault, Neutrophils trigger a NF-?B dependent polarization of tumor-supportive stromal cells in germinal center Bcell lymphomas, Oncotarget, vol.6, pp.16471-16487, 2015.

P. Tattevin, D. Monnier, and O. Tribut, Enhanced indoleamine 2,3-dioxygenase activity in patients with severe sepsis and septic shock, J Infect Dis, vol.201, pp.956-966, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00744207

W. Qiu, Y. Hu, and T. E. Andersen, Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) regulates differentiation fate of human mesenchymal (stromal) stem cells through canonical Wnt signaling and C/EBP, J Biol Chem, vol.285, pp.14438-14449, 2010.

M. Nobis, D. Herrmann, and S. C. Warren, A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts, Cell Reports, vol.21, pp.274-288, 2017.

H. Gao, F. Volat, and L. Sandhow, CD36 Is a Marker of Human Adipocyte Progenitors with Pronounced Adipogenic and Triglyceride Accumulation Potential, Stem Cells, vol.35, pp.1799-1814, 2017.

A. Armulik, G. Genové, and C. Betsholtz, Pericytes: developmental, physiological, and pathological perspectives, problems, and promises, Developmental Cell, vol.21, pp.193-215, 2011.

J. Astarita, V. Lukacs-kornek, and P. Tayalia, Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks, Nat Immunol, vol.13, pp.499-510, 2012.

H. Li, R. Ghazanfari, and D. Zacharaki, Isolation and characterization of primary bone marrow mesenchymal stromal cells, Annals of the New York Academy of Sciences, vol.1370, pp.109-118, 2016.

M. Maumus, J. Peyrafitte, D. Angelo, and R. , Native human adipose stromal cells: localization, morphology and phenotype, International Journal of Obesity, vol.35, pp.1141-1153, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00617658

R. Navarro, M. Compte, and L. Álvarez-vallina, Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity, Front Immunol, vol.7, p.480, 2016.

J. A. Ankrum, J. F. Ong, and J. M. Karp, Mesenchymal stem cells: immune evasive, not immune privileged, Nature Biotechnology, vol.32, pp.252-260, 2014.

Y. Li and F. Lin, Mesenchymal stem cells are injured by complement after their contact with serum, Blood, vol.120, pp.3436-3443, 2012.

L. Bahr-von, B. Sundberg, and L. Lönnies, Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy, Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, vol.18, pp.557-564, 2012.

N. Espagnolle, A. Balguerie, and E. Arnaud, CD54-Mediated Interaction with Proinflammatory Macrophages Increases the Immunosuppressive Function of Human Mesenchymal Stromal Cells, Stem Cell Reports, vol.8, pp.961-976, 2017.

G. Wang, K. Cao, and K. Liu, Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells, Cell Death and Differentiation, vol.25, pp.1209-1223, 2018.

H. Choi, R. H. Lee, and N. Bazhanov, Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-?B signaling in resident macrophages, Blood, vol.118, pp.330-338, 2011.

M. François, R. Romieu-mourez, and M. Li, Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation, Molecular Therapy : the Journal of the American Society of Gene Therapy, vol.20, pp.187-195, 2012.

D. P. Dyer, J. M. Thomson, and A. Hermant, TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8, J Immunol, vol.192, pp.2177-2185, 2014.

A. Luque, I. Serrano, and J. M. Aran, Complement components as promoters of immunological tolerance in dendritic cells, Semin Cell Dev Biol, 2017.

C. Hsieh, H. Chou, and H. Yang, The role of complement component 3 (C3) in differentiation of myeloid-derived suppressor cells, Blood, vol.121, pp.1760-1768, 2013.

L. C. Davies, N. Heldring, and N. Kadri, Mesenchymal Stromal Cell Secretion of Programmed Death-1 Ligands Regulates T Cell Mediated Immunosuppression, Stem Cells, vol.35, pp.766-776, 2017.

X. Chen, Q. Liu, and W. Huang, Stanniocalcin-2 contributes to mesenchymal stromal cells attenuating murine contact hypersensitivity mainly via reducing CD8+ Tc1 cells, Cell Death & Disease, vol.9, p.548, 2018.

R. Chinnadurai, D. Rajan, and M. Qayed, Analysis of Mesenchymal Stromal Cells Using a Combinatorial Assay Matrix Approach. Cell Reports, vol.22, pp.2504-2517, 2018.

R. Gonzalez, Y. I. Lynch, P. J. Thompson, and E. E. , In vitro cytokine licensing induces persistent permissive chromatin at the Indoleamine 2,3-dioxygenase promoter, Cytotherapy, vol.18, pp.1114-1128, 2016.

D. L. Dewi, S. R. Mohapatra, and S. Blanco-cabañes, Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer, Oncoimmunology, vol.6, p.1274477, 2017.

C. Bénézech, E. Mader, and G. Desanti, Lymphotoxin-β Receptor Signaling through NF-κB2-RelB Pathway Reprograms Adipocyte Precursors as Lymph Node Stromal Cells, Immunity, vol.2012, pp.1-14

, up in BM-MSC CD97 0.969152142857143 2.14752331417284e-05 up in BM-MSC EPHB2 1.17125928571429 1.55551944064011e-05 up in BM-MSC AHR 1.44212928571429 1.16979720267013e-05 up in BM-MSC PTN 1.95590928571429 3.70571330934594e-05 up in BM-MSC