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Practical Chromatography-Free Synthesis of 2-Iodo-N,N-diisopropylferrocenecarboxamide and Further Transformations

Abstract : An efficient procedure able to deliver grams of racemic and enantioenriched 2-iodo- N , N -diisopropylferrocenecarboxamide without chromatographic purification was developed. To introduce the halogen, two procedures, one using the n BuLi-TMEDA chelate and one using a lithium amide in the presence of ZnCl (2) as in situ trap were developed. Further functionalization by Suzuki-Miyaura and Ullman-type cross-couplings was investigated to access a variety of ferrocene derivatives.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-02303395
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Submitted on : Monday, November 18, 2019 - 11:52:13 AM
Last modification on : Thursday, December 12, 2019 - 1:51:05 PM

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William Erb, Thierry Roisnel, Vincent Dorcet. Practical Chromatography-Free Synthesis of 2-Iodo-N,N-diisopropylferrocenecarboxamide and Further Transformations. SYNTHESIS, Georg Thieme Verlag, 2019, 51 (17), pp.3205-3213. ⟨10.1055/s-0039-1689917⟩. ⟨hal-02303395⟩

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