AlCl3-promoted reaction of cycloalkanones with hydrazones: a convenient direct synthesis of 4,5,6,7-tetrahydro-1H-indazoles and their analogues

Rima Laroum (1) , Fabienne Berrée (2) , Thierry Roisnel (2) , Vincent Dorcet (2) , Bertrand Carboni (2) , Abdelmadjid Debache (1)

1 UMC - Université frères Mentouri Constantine I
2 ISCR - Institut des Sciences Chimiques de Rennes

The AlCl3-promoted reactions of cycloalkanones with hydrazones are described. This approach represents a mild and operationally simple method to access 2,3-diaryl-4,5,6,7-tetrahydro-1H-indazoles and their analogues in good to moderate yields. (C) 2019 Elsevier Ltd. All rights reserved.

Keywords: Aluminum chloride; Cycloalkanones; Tetrahydroindazoles; Hydrazones

Domains: Chemical Sciences

Rima Laroum, Fabienne Berrée, Thierry Roisnel, Vincent Dorcet, Bertrand Carboni, et al.. AlCl3-promoted reaction of cycloalkanones with hydrazones: a convenient direct synthesis of 4,5,6,7-tetrahydro-1H-indazoles and their analogues. Tetrahedron Letters, 2019, 60 (35), pp.150988. ⟨10.1016/j.tetlet.2019.150988⟩. ⟨hal-02303397⟩