Sensitivity Analysis of a Left Ventricle Model in the Context of Intraventricular Dyssynchrony

Virginie Le Rolle (1) , Elena Galli (1) , David Danan (1) , Karim El Houari (1) , Arnaud Hubert (1) , Erwan Donal (1, 2) , Alfredo I Hernández (1)

1 LTSI - Laboratoire Traitement du Signal et de l'Image
2 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]

The objective of the current study was to propose a sensitivity analysis of a 3D left ventricle model in order to assess the influence of parameters on myocardial mechanical dispersion. A finite element model of LV electro-mechanical activity was proposed and a screening method was used to evaluate the sensitivity of model parameters on the standard deviation of time to peak strain. Results highlight the importance of propagation parameters associated with septal and lateral segments activation. Simulated curves were compared to myocardial strains, obtained from echocardiography of one healthy subject and one patient diagnosed with intraventricular dyssynchrony and coronary artery disease. Results show a close match between simulation and clinical strains and illustrate the model ability to reproduce myocardial strains in the context of intraventricular dyssynchrony.

Mots clés: Cardiac mechanics; Cardiac modeling; Clinical data; Intraventricular dyssynchrony; Cardiac Modeling; intraventricular dyssynchrony; clinical data

Domaines: Ingénierie biomédicale

Virginie Le Rolle, Elena Galli, David Danan, Karim El Houari, Arnaud Hubert, et al.. Sensitivity Analysis of a Left Ventricle Model in the Context of Intraventricular Dyssynchrony. Acta Biotheoretica, 2020, 68 (1), pp.45-59. ⟨10.1007/s10441-019-09362-y⟩. ⟨hal-02304379⟩