Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging

Limiao Shi (1) , Christophe Nguyen (2) , Morgane Daurat (2) , Abdelhamid Chiheb Dhieb (1) , Wajda Smirani (3) , Mireille Blanchard‐desce (4) , Magali Gary-Bobo (2) , Olivier Mongin (1) , Christine Paul-Roth (1) , Frédéric Paul (1)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
3 Université de Carthage - University of Carthage
4 ISM - Institut des Sciences Moléculaires

The photophysical properties of a new series of fluorenyl porphyrins bearing water-solubilising oligoethyleneglycol chains are described. These biocompatible compounds present very good two-photon absorption and singlet oxygen generation properties, while retaining some fluorescence in water. After testing in vitro on breast cancer cells, some of them were shown to be efficient non-toxic two-photon photosensitisers allowing for fluorescence imaging, thus demonstrating their theranostic potential.

Domains: Chemical Sciences; Medicinal Chemistry

Limiao Shi, Christophe Nguyen, Morgane Daurat, Abdelhamid Chiheb Dhieb, Wajda Smirani, et al.. Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging. Chemical Communications, 2019, 55 (81), pp.12231-12234. ⟨10.1039/c9cc05657b⟩. ⟨hal-02307031⟩