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Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging

Abstract : The photophysical properties of a new series of fluorenyl porphyrins bearing water-solubilising oligoethyleneglycol chains are described. These biocompatible compounds present very good two-photon absorption and singlet oxygen generation properties, while retaining some fluorescence in water. After testing in vitro on breast cancer cells, some of them were shown to be efficient non-toxic two-photon photosensitisers allowing for fluorescence imaging, thus demonstrating their theranostic potential.
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Limiao Shi, Christophe Nguyen, Morgane Daurat, Abdelhamid Chiheb Dhieb, Wajda Smirani, et al.. Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging. Chemical Communications, Royal Society of Chemistry, 2019, 55 (81), pp.12231-12234. ⟨10.1039/c9cc05657b⟩. ⟨hal-02307031⟩

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