Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging

Limiao Shi; Christophe Nguyen; Morgane Daurat; Abdelhamid Chiheb Dhieb; Wajda Smirani; Mireille Blanchard-Desce; Magali Gary-Bobo; Olivier Mongin; Christine Paul-Roth; Frederic Paul

Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging

Limiao Shi ¹ Christophe Nguyen ² Morgane Daurat ² Abdelhamid Chiheb Dhieb ¹ Wajda Smirani ³ Mireille Blanchard-Desce ⁴ Magali Gary-Bobo ² Olivier Mongin ¹ Christine Paul-Roth ¹ Frederic Paul ¹

1 ISCR - Institut des Sciences Chimiques de Rennes

2 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

3 Université de Carthage - University of Carthage

4 ISM - Institut des Sciences Moléculaires

Abstract : The photophysical properties of a new series of fluorenyl porphyrins bearing water-solubilising oligoethyleneglycol chains are described. These biocompatible compounds present very good two-photon absorption and singlet oxygen generation properties, while retaining some fluorescence in water. After testing in vitro on breast cancer cells, some of them were shown to be efficient non-toxic two-photon photosensitisers allowing for fluorescence imaging, thus demonstrating their theranostic potential.

Document type :

Journal articles

Domain :

Chemical Sciences

Complete list of metadatas

https://hal-univ-rennes1.archives-ouvertes.fr/hal-02307031
Contributor : Laurent Jonchère <>
Submitted on : Monday, October 7, 2019 - 11:31:17 AM
Last modification on : Tuesday, November 12, 2019 - 5:10:39 PM

Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging

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Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging

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