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RhoA pathway and actin regulation of the golgi/centriole complex

Abstract : In vertebrate cells, the Golgi apparatus is located in close proximity to the centriole. The architecture of the Golgi/centriole complex depends on a multitude of factors, including the actin filament cytoskeleton. In turn, both the Golgi and centriole act as the actin nucleation centers. Actin organization and polymerization also depend on the small GTPase RhoA pathway. In this chapter, we summarize the most current knowledge on how the genetic, magnetic, or pharmacologic interference with RhoA pathway and actin cytoskeleton directly or indirectly affects architecture, structure, and function of the Golgi/centriole complex.
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Submitted on : Monday, December 2, 2019 - 3:18:54 PM
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Malgorzata Kloc, Ahmed Uosef, Jarek Wosik, Jacek Kubiak, Rafik Ghobrial. RhoA pathway and actin regulation of the golgi/centriole complex. The Golgi Apparatus and Centriole. Results and Problems in Cell Differentiation, 67, Springer Verlag, pp.81-93, 2019, 978-3-030-23173-6. ⟨10.1007/978-3-030-23173-6_5⟩. ⟨hal-02309655⟩



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