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, La ferroportine (FPN) est l'effecteur permettant la libération de fer. L'oxydation du fer ferreux en fer ferrique, qui permet au fer de se lier à la transferrine et d'être délivré aux cellules, met en jeu la céruloplasmine et l'héphaestine (Heph). L'hepcidine limite la libération du fer dans le plasma en provoquant l