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Journal articles
Late-Stage Diversification of Imidazole-Based Pharmaceuticals through Pd-Catalyzed Regioselective C-H Bond Arylations
Abstract : Palladium-catalyzed C-H bond arylation of imidazoles has been applied to pharmaceuticals such as Bifonazole, Climbazole, and Prochloraz. In the presence of phosphine-free Pd(OAc)(2) catalyst, aryl bromides are efficiently coupled at the CS-position of the imidazole units, which are widely decorated. Under these conditions, only C-H bond arylation reaction occurred without affecting the integrity of chemical structure of the imidazole-based pharmaceuticals. Moreover, with Bifonazole Pd-catalyzed C-H bond diarylation at the C2- and C5-positions of imidazole unit has also been performed.
Cited literature [36 references]
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02359968
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, November 26, 2019 - 9:58:15 AM
Last modification on : Wednesday, April 7, 2021 - 3:18:12 PM
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, November 26, 2019 - 9:58:15 AM
Last modification on : Wednesday, April 7, 2021 - 3:18:12 PM
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