Y. Lu and A. I. Cederbaum, CYP2E1 and oxidative liver injury by alcohol. Free Radical Biology 3 and Medicine, vol.44, pp.723-761, 2008.

J. Machackova, J. Barta, and N. S. Dhalla, Myofibrillar remodeling in cardiac hypertrophy, heart 5 failure and cardiomyopathies, Can J Cardiol, vol.22, issue.11, pp.953-68, 2006.

M. M. Markoski, J. Garavaglia, A. Oliveira, J. Olivaes, and A. Marcadenti, Molecular Properties of

, Red Wine Compounds and Cardiometabolic Benefits. Nutrition and Metabolic 8 Insights, vol.9, 2016.

T. Matsui, H. Sakurai, T. Toyama, A. Yoshimura, S. Matsushita et al.,

, Nihon Arukoru Yakubutsu Igakkai, vol.11

. Zasshi, , vol.47, pp.125-159, 2012.

D. B. Maurel, N. Boisseau, C. L. Benhamou, and C. Jaffre, Alcohol and bone: review of dose effects 13 and mechanisms, Osteoporosis International, vol.23, issue.1, pp.1-16, 2012.

J. Mayfield, L. Ferguson, and R. A. Harris, Neuroimmune signaling: a key component of alcohol 15 abuse. Current Opinion in Neurobiology, vol.23, pp.513-533, 2013.

J. N. Mcclintick, J. A. Tischfield, L. Deng, M. Kapoor, X. Xuei et al., Ethanol activates 17 immune response in lymphoblastoid cells, Alcohol, vol.79, pp.81-91, 2019.

A. J. Mcevily, B. Holmquist, D. S. Auld, and B. L. Vallee, 3.beta.-Hydroxy-5.beta.-steroid 19 dehydrogenase activity of human liver alcohol dehydrogenase is specific to .gamma.-20 subunits, Biochemistry, vol.27, issue.12, pp.4284-4292, 1988.

P. E. Mcgovern, J. Zhang, J. Tang, Z. Zhang, G. R. Hall et al., , p.22

, Anti-Inflammatory Action of Alcohol. Catapano A, editor, PLoS ONE, vol.8, issue.11, p.78537, 0311.

A. Obad, A. Peeran, J. I. Little, G. E. Haddad, and S. T. Tarzami, Alcohol-Mediated Organ Damages: 5 Heart and Brain. Frontiers in Pharmacology, vol.9, 0625.


K. S. O'shea and M. H. Kaufman, The teratogenic effect of acetaldehyde: implications for the study 9 of the fetal alcohol syndrome, J Anat, vol.128, pp.65-76, 1979.

N. A. Osna, T. M. Donohue, and K. K. Kharbanda, Alcoholic Liver Disease: Pathogenesis and Current 11

, Management. Alcohol Res, vol.38, issue.2, pp.147-61, 2017.

A. Paganini-hill, C. H. Kawas, and M. M. Corrada, Lifestyle Factors and Dementia in the Oldest-old: 13 The 90+ Study, Alzheimer Disease & Associated Disorders, vol.30, issue.1, pp.21-27, 2016.

L. F. Panchenko, V. S. Moiseev, S. V. Pirozhkov, N. N. Terebilina, T. A. Naumova et al., 15 [Blood Content of Markers of Inflammation and Cytokines in Patients With Alcoholic 16

, Cardiomyopathy and Ischemic Heart Disease at Various Stages of Heart Failure

, Kardiologiia, vol.55, issue.3, pp.41-49, 2015.

M. Pang, S. Bala, K. Kodys, D. Catalano, and G. Szabo, Inhibition of TLR8-and TLR4-induced 19

, Type I IFN induction by alcohol is different from its effects on inflammatory cytokine 20 production in monocytes, BMC Immunology, vol.12, issue.1, p.55, 2011.

R. Peters, J. Peters, J. Warner, N. Beckett, and C. Bulpitt, Alcohol, dementia and cognitive decline in 22 consumption on self-ratings and observer ratings of foreign language skills, Journal of 2 Psychopharmacology, vol.32, issue.1, pp.116-138, 2018.

P. Rodrigues, S. Santos-ribeiro, T. T. Gomes, F. V. Leal, I. Reis et al., Association, vol.4

, Between Alcohol Intake and Cardiac Remodeling, Journal of the American College

, Cardiology, vol.72, issue.13, pp.1452-62, 2018.

R. D. Rohwer, S. Liu, N. You, J. E. Buring, and J. E. Manson,

, Alcohol Intake and Endogenous Sex-Steroid Hormones on Diabetes Risk in

P. Women, Journal of the American College of Nutrition, vol.34, pp.273-80, 1994.

J. Romeo, J. Wärnberg, L. E. Díaz, M. González-gross, and M. A. , Effects of moderate beer 11 consumption on first-line immunity of healthy adults, J Physiol Biochem, vol.63, issue.2, pp.153-162, 200712-06.

P. E. Ronksley, S. E. Brien, B. J. Turner, K. J. Mukamal, and W. A. Ghali, Association of alcohol 14 consumption with selected cardiovascular disease outcomes: a systematic review and 15 meta-analysis, BMJ, vol.342, p.671, 2011.

I. Sánchez-sellero, E. San-román-rodríguez, S. Santos-pérez, and M. Rossi-izquierdo, , p.17

A. , Alcohol consumption in Menière's disease patients, Nutritional Neuroscience, 2018.

D. Schapira, Alcohol abuse and osteoporosis. Semin Arthritis Rheum, vol.19, pp.371-377, 1990.

W. M. Schoonen, C. A. Salinas, L. Kiemeney, and J. L. Stanford, Alcohol consumption and risk of 21 prostate cancer in middle-aged men, International Journal of Cancer, vol.113, issue.1, pp.133-173, 0221.

I. C. Schrieks, A. Heil, H. Hendriks, K. J. Mukamal, and J. Beulens, The effect of alcohol 24 consumption on insulin sensitivity and glycemic status: a systematic review and meta-25 analysis of intervention studies, Diabetes Care, vol.38, issue.4, pp.723-755, 2015.

A. Schröck, A. Henzi, P. Bütikofer, S. König, and W. Weinmann, Determination of the formation 27 rate of phosphatidylethanol by phospholipase D (PLD) in blood and test of two 28 selective PLD inhibitors, Alcohol, vol.73, pp.1-7, 2018.

J. R. Scott, A. L. Hassett, A. D. Schrepf, C. M. Brummett, R. E. Harris et al., Moderate, vol.30

, Alcohol Consumption Is Associated with Reduced Pain and Fibromyalgia Symptoms 31 in Chronic Pain Patients. Pain Medicine [Internet], 2018.


H. K. Seitz, U. A. Simanowski, F. T. Garzon, J. M. Rideout, T. J. Peters et al., Possible role of 35 acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat, Gastroenterology, vol.36, issue.2, pp.406-419, 1990.

, Journal of Pharmacology and Experimental Therapeutics, vol.313, issue.1, pp.104-115, 2005.

Y. Shabtai, L. Bendelac, H. Jubran, J. Hirschberg, and A. Fainsod, Acetaldehyde inhibits retinoic 4 acid biosynthesis to mediate alcohol teratogenicity, Scientific Reports, 2018.

. Dec, , vol.8, 2018.

Y. Shabtai and A. Fainsod, Competition between ethanol clearance and retinoic acid biosynthesis 8 in the induction of fetal alcohol syndrome, Biochemistry and Cell Biology, 2018.

, Apr, vol.96, issue.2, pp.148-60

I. Shai, E. B. Rimm, M. B. Schulze, N. Rifai, M. J. Stampfer et al., Moderate alcohol intake and 11 markers of inflammation and endothelial dysfunction among diabetic men

, Diabetologia, vol.47, issue.10, pp.1760-1767, 2004.

Y. Shimizu, A. Sakai, K. Menuki, T. Mori, T. Isse et al., Reduced bone formation in 14 alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow 15 cells in aldehyde dehydrogenase 2-disrupted mice, Bone, vol.48, issue.5, pp.1075-86, 2011.

S. M. Silva, S. Silva, M. Meireles, and S. Leal, nNOS is involved in cardiac remodeling induced by 17 chronic ethanol consumption, Toxicology, vol.329, pp.98-105, 2015.

T. Skaaby, T. O. Kilpeläinen, A. E. Taylor, Y. Mahendran, A. Wong et al.,

, Association of alcohol consumption with allergic disease and asthma: a multicenter 20

, Mendelian Randomization analysis. Addiction [Internet], 2018.

C. Smith, M. Gasparetto, C. Jordan, D. A. Pollyea, and V. Vasiliou, , p.23

, Aldehyde Dehydrogenases on Disorders of Hematopoiesis, p.24

H. K. Seitz and J. B. Hoek, Biological Basis of Alcohol-Induced Cancer

. Cham, , vol.26, pp.349-59, 2015.

P. Steinbigler, R. Haberl, B. König, and G. Steinbeck, P-wave signal averaging identifies patients 28 prone to alcohol-induced paroxysmal atrial fibrillation, The American Journal, p.29

, Cardiology, vol.91, issue.4, pp.491-495, 2003.

S. Sureshchandra, A. Raus, A. Jankeel, B. Ligh, N. Walter et al., Dose-31 dependent effects of chronic alcohol drinking on peripheral immune responses

S. Sureshchandra, C. Stull, B. Ligh, S. B. Nguyen, K. A. Grant et al., Chronic heavy 35 drinking drives distinct transcriptional and epigenetic changes in splenic macrophages

. Ebiomedicine, , vol.43, pp.594-606, 2019.

. Vs and . High, Alcohol: Central Benefits Vs. Detriments. Neurotoxicity Research

, , 2018.

T. Tsuchiya, A. Sakai, K. Menuki, T. Mori, Y. Takeuchi et al., , vol.5

, dehydrogenase 2 gene results in altered cortical bone structure and increased cortical 6 bone mineral density in the femoral diaphysis of mice, Bone, vol.53, issue.2, pp.358-68, 2013.

A. Urbano-márquez and J. Fernández-solà,

, Alcoholic Myopathy. Muscle & Nerve, vol.30, issue.6, pp.689-707, 2004.

M. Uusi-oukari and E. R. Korpi, Regulation of GABAA Receptor Subunit Expression by 10 Pharmacological Agents, Pharmacological Reviews, vol.62, issue.1, pp.97-135, 2010.

C. F. Valenzuela, S. Bhave, P. Hoffman, and R. A. Harris, Acute effects of ethanol on 12 pharmacologically isolated kainate receptors in cerebellar granule neurons: 13 comparison with NMDA and AMPA receptors, J Neurochem, vol.71, issue.4, p.1777, 1998.

V. Vasiliou and A. Pappa, Polymorphisms of Human Aldehyde Dehydrogenases, Pharmacology, vol.16, issue.3, pp.192-200, 2000.

R. P. Vetreno, J. M. Hall, and L. M. Savage, Alcohol-related amnesia and dementia: Animal models 18 have revealed the contributions of different etiological factors on neuropathology, 19 neurochemical dysfunction and cognitive impairment. Neurobiology of Learning and 20 Memory, vol.96, pp.596-608, 2011.

M. Victor, Alcoholic dementia, Can J Neurol Sci, vol.21, issue.2, pp.88-99, 1994.

M. Wang, E. J. Mcintee, G. Cheng, Y. Shi, P. W. Villalta et al., Identification of DNA adducts 23 of acetaldehyde, Chem Res Toxicol, vol.13, issue.11, pp.1149-57, 2000.

M. Q. Wang, M. E. Nicholson, B. S. Mahoney, Y. Li, and M. A. Perko, Proprioceptive Responses under 25 Rising and Falling BACs: A Test of the Mellanby Effect. Perceptual and Motor Skills, vol.26, pp.83-91, 1993.

D. J. Wattendorf and M. Muenke, Fetal alcohol spectrum disorders, Am Fam Physician, vol.72, issue.2, p.285, 2005.

X. Wei, X. Shi, W. Zhong, Y. Zhao, Y. Tang et al., Chronic Alcohol Exposure Disturbs 30

, Lipid Homeostasis at the Adipose Tissue-Liver Axis in Mice: Analysis of 31

, Triacylglycerols Using High-Resolution Mass Spectrometry in Combination with, p.32

W. Wimer, J. Russel, and H. Kaplan, Alcohols toxicology. Park Ridg : Noyes Data Corp, 1983.

, World Health Organization. Global status report on alcohol and health, p.36, 2011.

Y. Zhou, J. Zheng, S. Li, T. Zhou, P. Zhang et al., Alcoholic Beverage Consumption and 3

, Chronic Diseases, International Journal of Environmental Research and Public Health, vol.4, issue.6, p.522, 2016.

A. Zhukov, M. Ingelman-sundberg, and . Faris, Relationship between cytochrome P450 catalytic cycling 6 and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) 7 in hepatoma cells is abolished by inactivation of its electron donor NADPH-8 cytochrome P450 reductase, Biochem J, vol.340, issue.2, pp.453-461, 1999.

U. and F. , , 2004.

. Fernandezsola,

. Gürtl, , 2009.

. Laonigro, References Cardiovascular mortality Antioxidant and hypotensive responses Elevated HDL cholesterol Low LDL cholesterol and reduced blood coagulation Inhibition of the NLRP3 inflammasome, Agarwal, 2002.

. Gil-bernabe,

. Arranz, , 2012.

. Nurmi, Ková? and Zemánková, 2013.

. Rodrigues, , 2018.