Tc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma

Christopher Montemagno (1, 2) , Shamir Cassim (1) , Dimitry Trichanh (2) , Clara Savary (3) , Jacques Pouysségur (4, 1) , Gilles Pagès (4, 1) , Daniel Fagret (2) , Alexis Broisat (2) , Catherine Ghezzi (2)

1 CSM - Centre Scientifique de Monaco
2 LRB - Radiopharmaceutiques biocliniques
3 IGDR - Institut de Génétique et Développement de Rennes
4 IRCAN - Institut de Recherche sur le Cancer et le Vieillissement

Mesothelin is a membrane-associated protein overexpressed in pancreatic ductal adenocarcinoma (PDAC). Some mesothelin-targeted therapies are in clinical development but the identification of patients eligible for such therapies is still challenging. The objective of this study was to perform the imaging of mesothelin in mice models of PDAC with a technetium-labeled anti-mesothelin single-domain antibody (Tc-A1).

Keywords: Mesothelin; PDAC; noninvasive imaging

Domains: Life Sciences [q-bio]

Christopher Montemagno, Shamir Cassim, Dimitry Trichanh, Clara Savary, Jacques Pouysségur, et al.. Tc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma. Cancers, 2019, 11 (10), ⟨10.3390/cancers11101531⟩. ⟨hal-02364601⟩