Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship, Mayo Clin. Proc, vol.83, pp.584-594, 2008. ,
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression, Nature, vol.442, pp.96-99, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-02154247
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2, Nature, vol.442, pp.100-103, 2006. ,
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation, Mol. Cell, vol.21, pp.51-64, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-02154286
The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: Implications for the regulation of energy metabolism, J. Biol. Chem, vol.278, pp.37840-37848, 2003. ,
Pedeux, R. ING2 controls the progression of DNA replication forks to maintain genome stability, EMBO Rep, vol.10, pp.1168-1174, 2009. ,
ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation, Mol. Cell. Biol, vol.25, pp.6639-6648, 2005. ,
The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation, Cancer Res, vol.66, 1906. ,
Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas, PLoS ONE, vol.5, 2010. ,
Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation, Nat. Genet, vol.14, pp.415-420, 1996. ,
Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor, Cytogenet. Cell Genet, vol.83, pp.232-235, 1998. ,
DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53, Proc. Natl. Acad. Sci, vol.98, pp.9671-9676, 2001. ,
A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis, Oncogene, vol.22, pp.343-350, 2003. ,
, Cancer Res, vol.63, pp.2373-2378, 2003.
A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis, FEBS Lett, vol.582, pp.3868-3874, 2008. ,
Crystal structure of the nucleosome core particle at 2.8 A resolution, Nature, vol.389, pp.251-260, 1997. ,
The occurrence of epsilon-n-methyl lysine in histones, Biochemistry, vol.3, pp.10-15, 1964. ,
Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs, J. Biol. Chem, vol.283, 2008. ,
Genomic maps and comparative analysis of histone modifications in human and mouse, Cell, vol.120, pp.169-181, 2005. ,
Active genes are tri-methylated at K4 of histone H3, Nature, vol.419, pp.407-411, 2002. ,
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor, Cell, vol.114, pp.99-111, 2003. ,
The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding, J. Biol. Chem, vol.281, pp.28831-28836, 2006. ,
Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage, Sci. Rep, 2013. ,
ING2, a tumor associated gene, enhances PAI-1 and HSPA1A expression with HDAC1 and mSin3A through the PHD domain and C-terminal, Mol. Med. Rep, vol.16, pp.7367-7374, 2017. ,
Sumoylation of ING2 regulates the transcription mediated by Sin3A, Oncogene, vol.29, pp.5946-5956, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-02345546
Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex, Cell, vol.89, pp.357-364, 1997. ,
The major cytoplasmic histone acetyltransferase in yeast: Links to chromatin replication and histone metabolism, Cell, vol.87, pp.85-94, 1996. ,
of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors, Mol. Cell, vol.2, pp.33-42, 1998. ,
, Mol. Cell, vol.1, pp.1021-1031, 1998.
Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex, Mol. Cell. Biol, vol.22, pp.2743-2750, 2002. ,
Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: Coupling protein O-GlcNAcylation to transcriptional repression, Cell, vol.110, pp.69-80, 2002. ,
Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex, J. Biol. Chem, vol.287, pp.32346-32353, 2012. ,
Identification and characterization of three new components of the mSin3A corepressor complex, Mol. Cell. Biol, vol.23, pp.3456-3467, 2003. ,
Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression, Genes Dev, vol.16, pp.687-692, 2002. ,
Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex, Mol. Cell. Biol, vol.24, pp.306-319, 2004. ,
ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression, Int. J. Cancer, vol.125, pp.1306-1315, 2009. ,
Suberoylanilide hydroxamic acid (SAHA)-induced dynamics of a human histone deacetylase protein interaction network, Mol. Cell Proteomics, vol.13, pp.3114-3125, 2014. ,
Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence, Cancer Res, vol.68, pp.3193-3203, 2008. ,
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a, Cell, vol.88, pp.593-602, 1997. ,
Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents, Blood, vol.82, pp.1092-1096, 1993. ,
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6, Nature, vol.352, pp.345-347, 1991. ,
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts, Genes Dev, vol.8, pp.2540-2551, 1994. ,
Nuclear ING2 expression is reduced in human cutaneous melanomas, Br. J. Cancer, vol.95, pp.80-86, 2006. ,
Decreased expression of ING2 gene and its clinicopathological significance in hepatocellular carcinoma, Cancer Lett, vol.261, pp.183-192, 2008. ,
Expression profiles of inhibitor of growth protein 2 in normal and cancer tissues: An immunohistochemical screening analysis, Mol. Med. Rep, vol.13, pp.1881-1887, 2016. ,
Nuclear ING2 expression is reduced in osteosarcoma, Oncol. Rep, vol.32, 1967. ,
miR-153-3p Suppresses Inhibitor of Growth Protein 2 Expression to Function as Tumor Suppressor in Acute Lymphoblastic Leukemia, Technol. Cancer Res. Treat, vol.18, p.1533033819852990, 2019. ,
A novel tumor suppressor gene in basal cell carcinoma: Inhibition of growth factor-2, Tumour Biol, vol.36, pp.4611-4616, 2015. ,
Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer, Oncol. Rep, vol.15, pp.545-549, 2006. ,
Expression profiles of mRNA transcript variants encoding the human inhibitor of growth tumor suppressor gene family in normal and neoplastic tissues, Exp. Cell Res, vol.314, pp.273-285, 2008. ,
Tumor-promoting properties of miR-8084 in breast cancer through enhancing proliferation, suppressing apoptosis and inducing epithelial-mesenchymal transition, J. Transl. Med, vol.16, 2018. ,
Regulat-INGs in tumors and diseases: Focus on ncRNAs, Cancer Lett, vol.447, pp.66-74, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02015576
Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: Evidence for the involvement of p33ING2/ING1L and SAP30 genes, J. Cutan. Pathol, vol.31, pp.318-322, 2004. ,
Frequent deletion of ING2 locus at 4q35.1 associates with advanced tumor stage in head and neck squamous cell carcinoma, J. Cancer Res. Clin. Oncol, vol.135, pp.703-713, 2009. ,
Analysis of loss of heterozygosity on chromosome 4q in hepatocellular carcinoma using high-throughput SNP array, Oncol. Rep, vol.23, pp.445-455, 2010. ,
Allelic loss of the ING gene family loci is a frequent event in ameloblastoma, Oncol. Res, vol.18, pp.509-518, 2010. ,
Deletion mapping of chromosome 4q22-35 and identification of four frequently deleted regions in head and neck cancers, Neoplasma, vol.55, pp.299-304, 2008. ,
Molecular and immunohistochemical evidence for the origin of uterine leiomyosarcomas from associated leiomyoma and symplastic leiomyoma-like areas, Mod. Pathol, vol.22, pp.1303-1311, 2009. ,
Cell-free plasma hypermethylated CASZ1, CDH13 and ING2 are promising biomarkers of esophageal cancer, J. Biomed. Res, vol.32, pp.424-433, 2018. ,
The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data, Cancer Discov, vol.2, pp.401-404, 2012. ,
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal, Sci. Signal, vol.6, 2013. ,
Expression of candidate tumor suppressor gene ING2 is lost in non-small cell lung carcinoma, Lung Cancer, vol.69, pp.180-186, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-02345566
Decreased expression of ING2 gene and its clinicopathological significance in Chinese NSCLC patients, Neoplasma, vol.61, pp.468-475, 2014. ,
Whole genome microarray analysis in non-small cell lung cancer, Biotechnol. Biotechnol. Equip, vol.29, pp.111-118, 2015. ,
HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation, FEBS Lett, vol.584, pp.3005-3012, 2010. ,
Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKI?, vol.36, pp.5668-5680, 2017. ,
Novel therapeutic targets on the horizon for lung cancer, Lancet Oncol, vol.17, pp.347-362, 2016. ,
The Biological and Clinical Relevance of Inhibitor of Growth (ING) Genes in Non-Small Cell Lung Cancer, Cancers, vol.11, 1118. ,
Defining a Cancer Dependency Map, vol.170, pp.564-576, 2017. ,
Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression, Cell, vol.89, pp.349-356, 1997. ,
The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development, Mol. Cell. Biol, vol.25, pp.6990-7004, 2005. ,
A. mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival, Genes Dev, vol.19, pp.1581-1595, 2005. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00708743
Sin3a regulates epithelial progenitor cell fate during lung development, vol.144, pp.2618-2628, 2017. ,
Emerging Roles of Epigenetic Regulator Sin3 in Cancer, Adv. Cancer Res, vol.130, pp.113-135, 2016. ,
Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer, Mol. Cancer Ther, vol.14, pp.1824-1836, 2015. ,
Sin3a is essential for the genome integrity and viability of pluripotent cells, Dev. Biol, vol.363, pp.62-73, 2012. ,
Deacetylase inhibitors dissociate the histone-targeting ING2 subunit from the Sin3 complex, Chem. Biol, vol.17, pp.65-74, 2010. ,
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation, Proc. Natl. Acad. Sci, vol.97, pp.10014-10019, 2000. ,
, Cell Cycle, vol.9, pp.3984-3990, 2010.
Targeting the cancer epigenome for therapy, Nat. Rev. Genet, vol.17, pp.630-641, 2016. ,
Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities, Mol. Cell. Biol, vol.20, pp.3807-3816, 2000. ,
Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas, Oncogene, vol.25, pp.857-866, 2006. ,
Implication for Cancer Stem Cells in Solid Cancer Chemo-Resistance: Promising Therapeutic Strategies Based on the Use of HDAC Inhibitors, J. Clin. Med, vol.8, p.912, 2019. ,
Dysregulation of histone deacetylases in carcinogenesis and tumor progression: A possible link to apoptosis and autophagy, Cell. Mol. Life Sci, vol.76, pp.3263-3282, 2019. ,
Histone Deacetylase Inhibitors as Anticancer Drugs, Int. J. Mol. Sci, vol.18, 1414. ,
, This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, © 2019 by the authors. Licensee MDPI