Skip to Main content Skip to Navigation
New interface
Journal articles

Mathematical models for kidney function focusing on clinical interest

Abstract : We give an overview of mathematical models of renal physiology and anatomy with the clinician in mind. Beyond the past focus on issues of local transport mechanisms along the nephron and the urine concentrating mechanism, recent models have brought insight into difficult problems such as renal ischemia (oxygen and CO2 diffusion in the medulla) or calcium and potassium homeostasis. They have also provided revealing 3D reconstructions of the full trajectories of families of nephrons and collecting ducts through cortex and medulla. The recent appearance of sophisticated whole-kidney models representing nephrons and their associated renal vasculature promises more realistic simulation of renal pathologies and pharmacological treatments in the foreseeable future.
Document type :
Journal articles
Complete list of metadata

Cited literature [74 references]  Display  Hide  Download
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Wednesday, December 11, 2019 - 5:01:59 PM
Last modification on : Wednesday, September 14, 2022 - 10:20:04 AM
Long-term archiving on: : Thursday, March 12, 2020 - 10:57:28 PM


Thomas-2019-Mathematical model...
Files produced by the author(s)



S Randall Thomas. Mathematical models for kidney function focusing on clinical interest. Morphologie, 2019, 103 (343), pp.161-168. ⟨10.1016/j.morpho.2019.10.043⟩. ⟨hal-02393817⟩



Record views


Files downloads