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Incidence and clearance of anal HPV-16 and HPV-18 infection, and their determinants, among HIV-infected men who have sex with men in France

Catharina J Alberts 1 Isabelle Heard 2, 3 Ana Canestri 4 Lucie Marchand 5 Jean-François Fléjou 6, 7 Lionel Piroth 8, 9 Tristan Ferry 10 Jean-Michel Didelot 11, 12 Laurent Siproudhis 13, 14, 15 Sebastien Henno 13 Isabelle Poizot-Martin 16 Teresa M Darragh 17 Gary M Clifford 1, * Jean-Damien Combes 1 Isabelle Etienney 18
Abstract : BACKGROUND: Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). METHODS: We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n = 438, 2014-2018). RESULTS: Human papillomavirus-16 and HPV-18 incidence were similar (~10% incident infections at 24 months). Human papillomavirus-16 incidence was higher among high-grade versus no lesion at baseline (adjusted incidence rate ratio = 3.0; 95% confidence interval, 1.07-8.18). Human papillomavirus-16 cleared significantly slower than HPV-18 (32% versus 54% by 24 months). CONCLUSIONS: In conclusion, anal HPV-16 is more persistent than HPV-18, and its incidence correlates with a prior detection of high-grade lesions.
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Catharina J Alberts, Isabelle Heard, Ana Canestri, Lucie Marchand, Jean-François Fléjou, et al.. Incidence and clearance of anal HPV-16 and HPV-18 infection, and their determinants, among HIV-infected men who have sex with men in France. Journal of Infectious Diseases, Oxford University Press (OUP), 2019, 221 (9), pp.1488-1493. ⟨10.1093/infdis/jiz623⟩. ⟨hal-02394262⟩

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