Characterization of environmental multi-exposure to pesticides in pregnant women

Lucas Regnaut (1) , Fabien Mercier (1) , Barbara Le Bot (1) , Cecile Chevrier (1) , Nathalie Bonvallot (2, 3, 1)

1 Irset - Institut de recherche en santé, environnement et travail
2 DSETGS - Département Santé Environnement Travail et Génie Sanitaire
3 EHESP - École des Hautes Études en Santé Publique [EHESP]

The objective was to develop a multi-residue approach to quantify different pesticides in urine from pregnant women and to assess their determinants of exposure. 244 urine samples from a mother-child cohort were analyzed by UHPLC/QTOFMS after a sample preparation step to look for 42 different molecules. Bayesian statistical analyses were used to study the determinants of exposure to >10% detected pesticides. Methylated organophosphorous (OP) were the most concentrated (600 µg/L). Determinants of exposure were: location in rural zone and proximity / presence of crops, diet, and smoking status. Surprisingly, an inverse association between the presence of potatoes or peas crops in the town of residence and urinary metabolites of pyrethroids was found.

Keywords: biological monitoring; multiresidue; pesticide exposure

Domains: Life Sciences [q-bio]; Santé publique et épidémiologie

Lucas Regnaut, Fabien Mercier, Barbara Le Bot, Cecile Chevrier, Nathalie Bonvallot. Characterization of environmental multi-exposure to pesticides in pregnant women. ISES-ISIAQ 2019, Aug 2019, Kaunas, Lithuania. ⟨hal-02436671⟩