Skip to Main content Skip to Navigation
Journal articles

Synthesis of Bridged Tetrahydrobenzo[b]azepines and Derivatives through an Aza-Piancatelli Cyclization/Michael Addition Sequence

Abstract : Herein, we report the preparation of bridged tetrahydrobenzo[b]azepines, which was accomplished through an aza-Piancatelli cyclization/Michael addition sequence in a one-pot fashion from readily available precursors. It is noteworthy that a general method to access these scaffolds was hitherto unprecedented. Additionally, the multifaceted aspects of this process have been exemplified through its application to the synthesis of 2-azabicyclo[3.2.1]octanes and bridged tetrahydrobenzo[b]oxepines, along with post-derivatizations.
Document type :
Journal articles
Complete list of metadatas

Cited literature [31 references]  Display  Hide  Download

https://hal-univ-rennes1.archives-ouvertes.fr/hal-02438534
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, February 11, 2020 - 4:40:33 PM
Last modification on : Saturday, October 3, 2020 - 4:15:43 AM
Long-term archiving on: : Tuesday, May 12, 2020 - 4:28:39 PM

File

Wang et al-Synthesis of Bridge...
Files produced by the author(s)

Identifiers

Citation

Shengdong Wang, Régis Guillot, Jean-François Carpentier, Yann Sarazin, Christophe Bour, et al.. Synthesis of Bridged Tetrahydrobenzo[b]azepines and Derivatives through an Aza-Piancatelli Cyclization/Michael Addition Sequence. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2020, 59 (3), pp.1134-1138. ⟨10.1002/anie.201911761⟩. ⟨hal-02438534⟩

Share

Metrics

Record views

62

Files downloads

90