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Synthesis of New gamma-Lactams with gem-Difluorinated Side Chains

Abstract : A short and efficient approach has been designed for the synthesis of new gamma-lactams that feature gem -difluorinated side-chains in position 4. The key steps involve 1,4-addition of nitroalkane anions on electrophilic gem -difluoroalkenes, followed by a cascade nitro reduction-heterocyclization. This flexible strategy also allows easy introduction of substituents in positions 3 or 5.
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https://hal-univ-rennes1.archives-ouvertes.fr/hal-02438548
Contributor : Laurent Jonchère <>
Submitted on : Tuesday, January 14, 2020 - 11:49:11 AM
Last modification on : Thursday, July 16, 2020 - 3:17:18 AM

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Ali Soulieman, Nicolas Gouault, Thierry Roisnel, Frédéric Justaud, Joël Boustie, et al.. Synthesis of New gamma-Lactams with gem-Difluorinated Side Chains. SYNLETT, Georg Thieme Verlag, 2019, 30 (20), pp.2258-2262. ⟨10.1055/s-0039-1690715⟩. ⟨hal-02438548⟩

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