Skip to Main content Skip to Navigation
Journal articles

Synthesis of New gamma-Lactams with gem-Difluorinated Side Chains

Abstract : A short and efficient approach has been designed for the synthesis of new gamma-lactams that feature gem -difluorinated side-chains in position 4. The key steps involve 1,4-addition of nitroalkane anions on electrophilic gem -difluoroalkenes, followed by a cascade nitro reduction-heterocyclization. This flexible strategy also allows easy introduction of substituents in positions 3 or 5.
Document type :
Journal articles
Complete list of metadata
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Tuesday, January 14, 2020 - 11:49:11 AM
Last modification on : Friday, November 26, 2021 - 2:46:29 PM



Ali Soulieman, Nicolas Gouault, Thierry Roisnel, Frédéric Justaud, Joël Boustie, et al.. Synthesis of New gamma-Lactams with gem-Difluorinated Side Chains. SYNLETT, Georg Thieme Verlag, 2019, 30 (20), pp.2258-2262. ⟨10.1055/s-0039-1690715⟩. ⟨hal-02438548⟩



Record views